Phenotypes associated with this allele

• Allele Symbol: Pou4f1^tm1Rsd
• Allele Name: targeted mutation 1, Michael G Rosenfeld
• Allele ID: MGI:3512302
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou4f1^tm1Rsd/Pou4f1^tm1Rsd	involves: 129S4/SvJae	MGI:3512564

Genotype
MGI:3512564

hm1

• Allelic Composition: Pou4f1^tm1Rsd/Pou4f1^tm1Rsd
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:37118 )

• death within the first 24 hours after birth

behavior/neurological

aphagia ( J:37118 )

• ineffective swallowing

impaired righting response ( J:37118 )

• inability to right themselves

abnormal stationary movement ( J:37118 )

• occasional abnormal movement and posture

nervous system

absent red nucleus ( J:37118 )

• absence of red nucleus

abnormal hindbrain morphology ( J:37118 )

• neurons lost between E16.5 and tearly in the first day after birth

• compact formation neurons absent

• absence of motor neurons for the esophagus and those controlling the peristaltic phase of swallowing

abnormal inferior olivary complex morphology ( J:37118 )

• absence of multiple subunits of the inferior olive

cochlear ganglion hypoplasia ( J:37118 )

• loss of cellularity in the acoustic ganglia

small trigeminal ganglion ( J:37118 )

• loss of cellularity in dorsal division of the trigeminal ganglia

• trigeminal ganglia normal through E16.5

small dorsal root ganglion ( J:37118 )

• loss of cellularity in the cervical dorsal root ganglia