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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac3tm1Hkp
targeted mutation 1, Nora C Hesterkamp
MGI:3512107
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rac3tm1Hkp/Rac3tm1Hkp B6.129-Rac3tm1Hkp MGI:3582412
cx2
 		Rac3tm1Hkp/Rac3tm1Hkp
Tg(BCR/ABL)623Hkp/0 		involves: C57BL/6 * C57BL/6J * CBA MGI:3582413


Genotype
MGI:3582412
hm1
Allelic
Composition		 Rac3tm1Hkp/Rac3tm1Hkp
Genetic
Background		 B6.129-Rac3tm1Hkp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac3tm1Hkp mutation (1 available); any Rac3 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:99168 )
N
• steady-state hematopoiesis of the peripheral blood, bone marrow, and spleen is normal




Genotype
MGI:3582413
cx2
Allelic
Composition		 Rac3tm1Hkp/Rac3tm1Hkp
Tg(BCR/ABL)623Hkp/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac3tm1Hkp mutation (1 available); any Rac3 mutation (13 available)
Tg(BCR/ABL)623Hkp mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:99168 )
• mean life span for females is 321 +/- 59 days significantly longer than females wild-type for Rac3 (193 +/- 29 days); however, mean life span for males is not significantly different from males wild-type for Rac3

neoplasm
increased leukemia incidence ( J:99168 )
• mutants develop B-lineage lymphoblastic leukemia




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory