Phenotypes associated with this allele

• Allele Symbol: Rac3^tm1Hkp
• Allele Name: targeted mutation 1, Nora C Hesterkamp
• Allele ID: MGI:3512107
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rac3^tm1Hkp/Rac3^tm1Hkp	B6.129-Rac3^tm1Hkp	MGI:3582412
cx2	Rac3^tm1Hkp/Rac3^tm1Hkp Tg(BCR/ABL)623Hkp/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:3582413

Genotype
MGI:3582412

hm1

• Allelic Composition: Rac3^tm1Hkp/Rac3^tm1Hkp
• Genetic Background: B6.129-Rac3^tm1Hkp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:99168 )

N • steady-state hematopoiesis of the peripheral blood, bone marrow, and spleen is normal

Genotype
MGI:3582413

cx2

• Allelic Composition: Rac3^tm1Hkp/Rac3^tm1Hkp; Tg(BCR/ABL)623Hkp/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

mortality/aging

premature death ( J:99168 )

• mean life span for females is 321 +/- 59 days significantly longer than females wild-type for Rac3 (193 +/- 29 days); however, mean life span for males is not significantly different from males wild-type for Rac3

neoplasm

increased leukemia incidence ( J:99168 )

• mutants develop B-lineage lymphoblastic leukemia