All Phenotypes Pdgfrb<tm1Rheu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdgfrb^tm1Rheu
targeted mutation 1, Rainer Heuchel
MGI:3511432

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfrb^tm1Rheu/Pdgfrb^tm1Rheu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3511444

Allelic Composition	Pdgfrb^tm1Rheu/Pdgfrb^tm1Rheu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Rheu mutation (0 available); any Pdgfrb mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast apoptosis ( J:93973 )

• mutant MEFs were more resistant to apoptosis than wild-type

abnormal fibroblast migration ( J:93973 )

• in the absence of stimulation, mutant MEFs showed a strong tendency to migrate into a wounded area compared to wild-type MEFs

hematopoietic system

abnormal embryonic hematopoiesis ( J:138069 )

• at E9.5, the number of CD41+ early hematopietic cells in the yolk sac is decreased 36% compared to in wild-type mice

embryo

abnormal embryonic hematopoiesis ( J:138069 )

• at E9.5, the number of CD41+ early hematopietic cells in the yolk sac is decreased 36% compared to in wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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