All Phenotypes Pdgfc<tm1Nagy> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	involves: 129S1/Sv * 129X1/SvJ	MGI:3511132
hm2	Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5548181
cx3	Pdgfa^tm2Cbet/Pdgfa^tm2Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	B6.129-Pdgfc^tm1Nagy Pdgfa^tm2Cbet	MGI:5548180
cx4	Pdgfa^tm1Cbet/Pdgfa^tm1Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	involves: 129S1/Sv * 129X1/SvJ	MGI:3511133
cx5	Pdgfa^tm2Cbet/Pdgfa^tm2Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5548178
cx6	Pdgfa^tm1Cbet/Pdgfa⁺ Pdgfc^tm1Nagy/Pdgfc^tm1Nagy	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5548182

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:93954 )

• 95% of mutants die within 1 day of birth

postnatal lethality, complete penetrance ( J:93954 )

• no homozygotes survive to weaning

craniofacial

abnormal palate bone morphology ( J:93954 )

• failure of the palatal bones to extend across the roof of the oronasal cavity

abnormal palatal shelf fusion at midline ( J:93954 )

• by E15.5, the palatal shelves were hypoplastic and failed to fuse

• the number of medial edge epithelial cells is reduced and those present lack filopodia probably contributing to the failure of mutant palatal shelves to fuse even when brought into close contact in vitro

palatal shelf hypoplasia ( J:93954 )

cleft secondary palate ( J:93954 )

• mutants that die shortly after birth have a complete cleft of the secondary palate

failure of palatal shelf elevation ( J:93954 )

• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away

short nasal septum ( J:93954 )

• the nasal septum is shorter than normal

homeostasis/metabolism

edema ( J:93954 )

• subcutaneous edema is seen in the flank of the body between the limbs

respiratory system

short nasal septum ( J:93954 )

• the nasal septum is shorter than normal

digestive/alimentary system

abnormal palate bone morphology ( J:93954 )

• failure of the palatal bones to extend across the roof of the oronasal cavity

abnormal palatal shelf fusion at midline ( J:93954 )

• by E15.5, the palatal shelves were hypoplastic and failed to fuse

palatal shelf hypoplasia ( J:93954 )

cleft secondary palate ( J:93954 )

• mutants that die shortly after birth have a complete cleft of the secondary palate

failure of palatal shelf elevation ( J:93954 )

• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away

embryo

spina bifida occulta ( J:93954 )

• develops in the lower spine and is evident at birth

nervous system

spina bifida occulta ( J:93954 )

• develops in the lower spine and is evident at birth

skeleton

abnormal palate bone morphology ( J:93954 )

• failure of the palatal bones to extend across the roof of the oronasal cavity

spina bifida occulta ( J:93954 )

• develops in the lower spine and is evident at birth

integument

blistering ( J:93954 )

• severe blistering, often filled with blood, is seen in the frontonasal and lateral forehead region

• subepithelial blistering is seen in the posterior portion of the secondary palate and nasal septum

growth/size/body

abnormal palate bone morphology ( J:93954 )

• failure of the palatal bones to extend across the roof of the oronasal cavity

abnormal palatal shelf fusion at midline ( J:93954 )

• by E15.5, the palatal shelves were hypoplastic and failed to fuse

palatal shelf hypoplasia ( J:93954 )

cleft secondary palate ( J:93954 )

• mutants that die shortly after birth have a complete cleft of the secondary palate

failure of palatal shelf elevation ( J:93954 )

• at E14.5, the palatal shelves failed to elevate, even when the tongue had moved away

short nasal septum ( J:93954 )

• the nasal septum is shorter than normal

Allelic Composition	Pdgfc^tm1Nagy/Pdgfc^tm1Nagy
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfc^tm1Nagy mutation (0 available); any Pdgfc mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased small intestinal villus number ( J:205009 )

• reduced number of villi in the upper small intestine

embryo

spina bifida occulta ( J:205009 )

nervous system

spina bifida occulta ( J:205009 )

skeleton

spina bifida occulta ( J:205009 )

Allelic Composition	Pdgfa^tm2Cbet/Pdgfa^tm2Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy
Genetic Background	B6.129-Pdgfc^tm1Nagy Pdgfa^tm2Cbet

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfa^tm2Cbet mutation (1 available); any Pdgfa mutation (19 available)
Pdgfc^tm1Nagy mutation (0 available); any Pdgfc mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:205009 )

• in all mice, but heterogeneity in severity

spina bifida occulta ( J:205009 )

• in 2 of 5 mice

nervous system

spina bifida ( J:205009 )

• in all mice, but heterogeneity in severity

spina bifida occulta ( J:205009 )

• in 2 of 5 mice

skeleton

spina bifida occulta ( J:205009 )

• in 2 of 5 mice

Allelic Composition	Pdgfa^tm1Cbet/Pdgfa^tm1Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfa^tm1Cbet mutation (0 available); any Pdgfa mutation (19 available)
Pdgfc^tm1Nagy mutation (0 available); any Pdgfc mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93954 )

• double homozygotes die after E10.5

cardiovascular system

common atrium ( J:93954 )

• at E15.5 atrial septa are absent in double homozygous embryos generated using tetraploid chimeras

pericardial effusion ( J:93954 )

• pericardial effusion is seen at E10.5

craniofacial

abnormal craniofacial bone morphology ( J:93954 )

• craniofacial bone defects similar to those in Pdgfra null embryos are seen

midline facial cleft ( J:93954 )

• at E11.5 a cleft face is seen in double homozygous embryos generated using tetraploid chimeras

embryo

decreased embryo size ( J:93954 )

• at E10.5 double homozygotes are growth retarded

spina bifida ( J:93954 )

• at E13.5 incomplete neural arch of vertebrae is seen in double homozygous embryos generated using tetraploid chimeras

wavy neural tube ( J:93954 )

• a wavy neural tube is seen at E10.5

abnormal somite development ( J:93954 )

• at E10.5 disorganized sclerotome, dermomyotome, and myotome is seen in somites of the cervical region of double homozygous embryos generated using tetraploid chimeras

growth/size/body

midline facial cleft ( J:93954 )

• at E11.5 a cleft face is seen in double homozygous embryos generated using tetraploid chimeras

decreased embryo size ( J:93954 )

• at E10.5 double homozygotes are growth retarded

homeostasis/metabolism

pericardial effusion ( J:93954 )

• pericardial effusion is seen at E10.5

hydrops fetalis ( J:93954 )

• edema is seen in double homozygous embryos generated using tetraploid chimeras

muscle

abnormal myotome development ( J:93954 )

• at E10.5 the myotome of somites in the lower occipital and cervical region is necrotic and poorly organized

• the metameric organization of myotomes in somites of the cervical region is disorganized at E10.5 in double homozygous embryos generated using tetraploid chimeras

renal/urinary system

abnormal kidney cortex morphology ( J:93954 )

• at E15.5 decreased interstitial mesenchyme is seen in the kidney cortex of double homozygous embryos generated using tetraploid chimeras

skeleton

abnormal scapula morphology ( J:93954 )

• at E14.5 retarded formation of the scapula is seen in double homozygous embryos generated using tetraploid chimeras

abnormal axial skeleton morphology ( J:93954 )

abnormal craniofacial bone morphology ( J:93954 )

• craniofacial bone defects similar to those in Pdgfra null embryos are seen

short sternum ( J:93954 )

• at E14.5 a short sternum is seen in double homozygous embryos generated using tetraploid chimeras

rib bifurcation ( J:93954 )

• at E14.5 rib bifurcations and fusions are seen in double homozygous embryos generated using tetraploid chimeras

rib fusion ( J:93954 )

• at E14.5 rib bifurcations and fusions are seen in double homozygous embryos generated using tetraploid chimeras

nervous system

spina bifida ( J:93954 )

• at E13.5 incomplete neural arch of vertebrae is seen in double homozygous embryos generated using tetraploid chimeras

wavy neural tube ( J:93954 )

• a wavy neural tube is seen at E10.5

integument

blistering ( J:93954 )

• subepidermal blistering is seen at E10.5

Allelic Composition	Pdgfa^tm2Cbet/Pdgfa^tm2Cbet Pdgfc^tm1Nagy/Pdgfc^tm1Nagy
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:205009 )

• in all mice

spina bifida occulta ( J:205009 )

• in some mice

digestive/alimentary system

abnormal small intestine morphology ( J:205009 )

• reduced thickness of the submucosal mesenchyme in the upper small intestine

decreased small intestinal villus number ( J:205009 )

• reduced number of villi in the upper small intestine

growth/size/body

decreased body size ( J:205009 )

skeleton

spina bifida occulta ( J:205009 )

• in some mice

kyphosis ( J:205009 )

• severe kyphosis of the thoracic spine in 3 of 11 mice

embryo

spina bifida ( J:205009 )

• in all mice

spina bifida occulta ( J:205009 )

• in some mice

Allelic Composition	Pdgfa^tm1Cbet/Pdgfa⁺ Pdgfc^tm1Nagy/Pdgfc^tm1Nagy
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

spina bifida ( J:205009 )

• severe in all mice

nervous system

spina bifida ( J:205009 )

• severe in all mice

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