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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lat2tm1Mal
targeted mutation 1, Bernard Malissen
MGI:3510698
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lat2tm1Mal/Lat2tm1Mal B6.129S2-Lat2tm1Mal MGI:3762499
hm2
 		Lat2tm1Mal/Lat2tm1Mal involves: 129S2/SvPas MGI:3511164
cx3
 		Lat2tm1Mal/Lat2tm1Mal
Lime1tm1.1Mal/Lime1tm1.1Mal 		involves: 129 * C57BL/6 MGI:3762495
cx4
 		Lattm2.1Mal/Lattm2.1Mal
Lat2tm1Mal/Lat2tm1Mal 		involves: 129S2/SvPas MGI:3511162


Genotype
MGI:3762499
hm1
Allelic
Composition		 Lat2tm1Mal/Lat2tm1Mal
Genetic
Background		 B6.129S2-Lat2tm1Mal
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Mal mutation (1 available); any Lat2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased anti-nuclear antigen antibody level ( J:126321 )
• detectable in 5 of 7 individuals




Genotype
MGI:3511164
hm2
Allelic
Composition		 Lat2tm1Mal/Lat2tm1Mal
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Mal mutation (1 available); any Lat2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:93950 )
• after antigen challenge, serum histamine levels were significantly higher than normal
• mast cell numbers were normal
• enhanced degranulation response seen in bone marrow mast cells

hematopoietic system
abnormal mast cell physiology ( J:93950 )
• after antigen challenge, serum histamine levels were significantly higher than normal
• mast cell numbers were normal
• enhanced degranulation response seen in bone marrow mast cells




Genotype
MGI:3762495
cx3
Allelic
Composition		 Lat2tm1Mal/Lat2tm1Mal
Lime1tm1.1Mal/Lime1tm1.1Mal
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Mal mutation (1 available); any Lat2 mutation (19 available)
Lime1tm1.1Mal mutation (1 available); any Lime1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased anti-nuclear antigen antibody level ( J:126321 )
• detectable in 5 of 7 individuals




Genotype
MGI:3511162
cx4
Allelic
Composition		 Lattm2.1Mal/Lattm2.1Mal
Lat2tm1Mal/Lat2tm1Mal
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Mal mutation (1 available); any Lat2 mutation (19 available)
Lattm2.1Mal mutation (0 available); any Lat mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:93950 )
• secretory responses of bone marrow mast cells were partially inhibited

hematopoietic system
abnormal mast cell physiology ( J:93950 )
• secretory responses of bone marrow mast cells were partially inhibited




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory