Phenotypes associated with this allele

• Allele Symbol: Tg(Tuba1-cre)1Tes
• Allele Name: transgene insertion 1, Lino Tessarollo
• Allele ID: MGI:3505769
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Txnrd1^tm1Marc/Txnrd1^tm1Marc Tg(Tuba1-cre)1Tes/0	involves: 129P2/OlaHsd	MGI:3778636
cn2	Ntrk1^tm1Tes/Ntrk1^tm1Tes Tg(Tuba1-cre)1Tes/0	involves: 129S1/Sv	MGI:3510463
cn3	Adm^tm1Mtnz/Adm^tm1Mtnz Tg(Tuba1-cre)1Tes/?	involves: 129S1/Sv * 129S4/SvJaeSor * C3H/HeJ * C57BL/6 * SJL	MGI:3811633
cn4	Trnau1ap^tm2.1Usch/Trnau1ap^tm2.1Usch Tg(Tuba1-cre)1Tes/0	involves: C57BL/6	MGI:5825446

Genotype
MGI:3778636

cn1

• Allelic Composition: Txnrd1^tm1Marc/Txnrd1^tm1Marc; Tg(Tuba1-cre)1Tes/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:133173 )

N • cerebellar foliation is normal

behavior/neurological

behavior/neurological phenotype ( J:133173 )

N • mice exhibit normal behavior

growth/size/body

growth/size/body region phenotype ( J:133173 )

N • mice exhibit normal growth

Genotype
MGI:3510463

cn2

• Allelic Composition: Ntrk1^tm1Tes/Ntrk1^tm1Tes; Tg(Tuba1-cre)1Tes/0
• Genetic Background: involves: 129S1/Sv

hematopoietic system

increased B-1 B cell number ( J:93578 )

• B1 cell numbers in the peritoneal cavity are increased by 30% in mice older than 12 months but not in younger animals

• no other immune cell morphological abnormalities were observed

abnormal mast cell physiology ( J:93578 )

• bone marrow mast cells release modestly but significantly reduced levels of beta-hexoseaminidase when stimulated

increased immunoglobulin level ( J:93578 )

increased IgG1 level ( J:93578 )

• increased serum levels of IgG1 and IgG2a

increased IgG2a level ( J:93578 )

increased IgM level ( J:93578 )

immune system

increased B-1 B cell number ( J:93578 )

• B1 cell numbers in the peritoneal cavity are increased by 30% in mice older than 12 months but not in younger animals

• no other immune cell morphological abnormalities were observed

abnormal mast cell physiology ( J:93578 )

• bone marrow mast cells release modestly but significantly reduced levels of beta-hexoseaminidase when stimulated

increased immunoglobulin level ( J:93578 )

increased IgG1 level ( J:93578 )

• increased serum levels of IgG1 and IgG2a

increased IgG2a level ( J:93578 )

increased IgM level ( J:93578 )

Genotype
MGI:3811633

cn3

• Allelic Composition: Adm^tm1Mtnz/Adm^tm1Mtnz; Tg(Tuba1-cre)1Tes/?
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C3H/HeJ * C57BL/6 * SJL

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:138817 )

• increased mortality in hypobaric condition

behavior/neurological

increased anxiety-related response ( J:138817 )

• at 6 and 12 month of age

impaired coordination ( J:138817 )

• at 3 months of age

increased vertical activity ( J:138817 )

• higher levels of horizontal and vertical activity at 3 months of age

• locomotor activity went down as the mice aged, becoming normal level by 9 months of age

increased locomotor activity ( J:138817 )

• higher levels of horizontal and vertical activity at 3 months of age

• locomotor activity went down as the mice aged, becoming normal level by 9 months of age

increased stereotypic behavior ( J:138817 )

• increase on stereotypy for the first 6 months of life

Genotype
MGI:5825446

cn4

• Allelic Composition: Trnau1ap^tm2.1Usch/Trnau1ap^tm2.1Usch; Tg(Tuba1-cre)1Tes/0
• Genetic Background: involves: C57BL/6

behavior/neurological

impaired coordination ( J:237714 )

• on a rotarod

nervous system

nervous system phenotype ( J:237714 )

N • mice exhibit normal cerebellar histology