Phenotypes associated with this allele

• Allele Symbol: Mcpt1^tm1Hrpm
• Allele Name: targeted mutation 1, Hugh R P Miller
• Allele ID: MGI:3505765
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcpt1^tm1Hrpm/Mcpt1^tm1Hrpm	involves: 129P2/OlaHsd * MF1	MGI:3510595

Genotype
MGI:3510595

hm1

• Allelic Composition: Mcpt1^tm1Hrpm/Mcpt1^tm1Hrpm
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:93616 )

• lower levels of apoptosis in the intestinal villi of mice infected with Trichinella spiralis

hematopoietic system

abnormal mast cell morphology ( J:93795 )

• significantly increased intestinal mucosal mast cell population by day 10 of N brasiliensis infection

• mast cells of smaller size and with more uniformly round granules which stain less intensly after infection

• granules lack crystalline structures

• granules with reduced esterase activity in infected individuals

• connective tissue mast cells were normal

immune system

abnormal mast cell morphology ( J:93795 )

• significantly increased intestinal mucosal mast cell population by day 10 of N brasiliensis infection

• mast cells of smaller size and with more uniformly round granules which stain less intensly after infection

• granules lack crystalline structures

• granules with reduced esterase activity in infected individuals

• connective tissue mast cells were normal

decreased circulating tumor necrosis factor level ( J:93616 )

• serum levels of TNF-alpha fail to become elevated in Trichinella spiralis infections as they do in control mice

increased susceptibility to parasitic infection ( J:93795 , J:93616 )

• increased succeptibility to Nippostrongylus brasiliensis infection (J:93795)

• higher larval burdens in Trichinella spiralis infections (J:93616)

homeostasis/metabolism

decreased circulating tumor necrosis factor level ( J:93616 )

• serum levels of TNF-alpha fail to become elevated in Trichinella spiralis infections as they do in control mice