Phenotypes associated with this allele

• Allele Symbol: Tg(Myl2SLC2A1)2Mue
• Allele Name: transgene insertion 2, Mike M Mueckler
• Allele ID: MGI:3505739
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myl2SLC2A1)2Mue/0	involves: C57BL/6 * SJL	MGI:3840082

Genotype
MGI:3840082

tg1

• Allelic Composition: Tg(Myl2SLC2A1)2Mue/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:93868 )

• 18% in fed mice and 30% in fasted mice compared to similarly treated wild-type mice

muscle

increased skeletal muscle cell glucose uptake ( J:93868 )

• skeletal muscle cells exhibit a 3- to 4-fold increase in basal glucose uptake compared to in wild-type muscle cells

• glucose uptake does not increase following insulin treatment as in wild-type cells

cellular

increased skeletal muscle cell glucose uptake ( J:93868 )

• skeletal muscle cells exhibit a 3- to 4-fold increase in basal glucose uptake compared to in wild-type muscle cells

• glucose uptake does not increase following insulin treatment as in wild-type cells