Analysis Tools
homeostasis/metabolism
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• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice
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Allele Symbol Allele Name Allele ID |
Tg(AZIP/F)1Vsn transgene insertion 1, Charles Vinson MGI:3497939 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• insulin content in the pancreata is increased compared to in wild-type mice
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• at birth and 2 weeks of age, mice exhibit increased serum insulin levels compared to in wild-type mice
• however, mice treated with isoproterenol exhibit lowered serum levels of insulin
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• beta-cell proliferation is increased compared to in wild-type mice
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• beta-cell proliferation, mass and area are increased compared to in wild-type mice
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• insulin content in the pancreata is increased compared to in wild-type mice
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• at 2 weeks of age
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• at 2 weeks of age
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• beta-cell proliferation is increased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transgenic mice are more sensitive to death after anesthesia than wild-type mice
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• survival after weaning is reduced
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• normal numbers of transgenic pups are born however by weaning the percentage of transgenic pups is decreased to 30% (from 50%)
• almost no pups from litters produced by hemizygous females survive until weaning
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• transgenic mice have decreased brown fat at birth which is primarily inactive and resembles white adipose tissue
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• transgenic mice have essentially no white fat as a result of a failure to generate white adipose tissue cells
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• transgenic mice drink 4 times more than wild-type mice
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• the islet cells are hyperplastic and hypertrophic with a large increase in the number of beta cells
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• when fasted adult transgenic mice lose weight faster than non-transgenic mice
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• transgenic mice are heavier than wild-type mice at 8-11 weeks of age as a result of an increase in the weights of multiple organs including the liver, heart, kidneys, and spleen
• transgenic mice have increased abdominal girth compared to wild-type mice
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• transgenic mice grow slower than wild-type mice before weaning, weighing 50% and 80% of wild-type weight at 1 and 3 weeks of age, respectively
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• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice
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• free active leptin levels are about 5% of wild-type mice
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• serum glucose is increased about 3-fold compared to wild-type mice
• elevated serum glucose is first detected 3 weeks after birth and reaches diabetic levels by 4 weeks
• when fasted serum glucose levels drop to a much greater extent than in non-transgenic mice
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• serum insulin levels are increased 58- and 442-fold in male and female transgenic mice
• insulin levels are already elevated 30-fold by 1 week after birth
• when fasted serum insulin levels drop to a much greater extent than in non-transgenic mice
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• circulating free fatty acid are increased 1.5- to 2.5 fold compared to wild-type mice however no signs of ketosis are detected
• when fasted circulating free fatty acid levels drop rather than rise as in wild-type mice
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• serum triglyceride levels are elevated 3- to 5-fold
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• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice
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• transgenic mice are more sensitive to death after anesthesia than wild-type mice
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• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice
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• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice
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• the liver is pale with lipid accumulation in a zone 3/centrilobular pattern
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• females have reduced fertility and litter size with almost no pups surviving until weaning
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• male fertility is decreased but litters that are produced are of normal size
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• lipid loaded phagocytic cells are seen in the lungs of some transgenic mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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