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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plod3tm1Soin
targeted mutation 1, Raija Soininen
MGI:3497741
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plod3tm1Soin/Plod3tm1Soin involves: 129 MGI:3510437


Genotype
MGI:3510437
hm1
Allelic
Composition
Plod3tm1Soin/Plod3tm1Soin
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plod3tm1Soin mutation (1 available); any Plod3 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos die around E9.5-E10.5

cellular
• at E9.5 in cells from homozygous embryos the basement membranes are fragmented, the endoplasmic reticulum is dilated, and the Golgi complexes and lysosomes are enlarged

embryo
• cellular density is decreased in homozygous embryos at E9.5
• homozygous embryos are developmentally retarded and fragile after E8.5
• at E8.5 homozygous embryos are about 60% of the size of wild-type littermates

growth/size/body
• homozygous embryos are developmentally retarded and fragile after E8.5
• at E8.5 homozygous embryos are about 60% of the size of wild-type littermates





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory