Phenotypes associated with this allele

• Allele Symbol: Dmbt1^tm1Qaa
• Allele Name: targeted mutation 1, Qais Al-Awqati
• Allele ID: MGI:3497714
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmbt1^tm1Qaa/Dmbt1^tm1Qaa	either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * SWR)	MGI:3510443

Genotype
MGI:3510443

hm1

• Allelic Composition: Dmbt1^tm1Qaa/Dmbt1^tm1Qaa
• Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * SWR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:93477 )

• embryos die between E4.5 and E5.5

cellular

abnormal inner cell mass apoptosis ( J:93477 )

• increased apoptosis is seen in mutant blastocysts after overnight culture compared to wild-type

embryo

abnormal inner cell mass apoptosis ( J:93477 )

• increased apoptosis is seen in mutant blastocysts after overnight culture compared to wild-type

absent egg cylinders ( J:93477 )

• inability to form the egg cylinder in outgrowth assay

abnormal inner cell mass morphology ( J:93477 )

• in a blastocyst outgrowth assay the inner cellular mass is absent or degenerating and embryos fail to form the egg cylinder

absent inner cell mass ( J:93477 )

inner cell mass degeneration ( J:93477 )