All Phenotypes Tg(GFAP-APOE_i2)14Hol MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(GFAP-APOE_i2)14Hol
transgene insertion 14, David M Holtzman
MGI:3057185

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(APPV717F)109Ili/0 Tg(GFAP-APOE_i2)14Hol/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3784387

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Tg(APPV717F)109Ili/0 Tg(GFAP-APOE_i2)14Hol/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (34 available); any Apoe mutation (162 available)
Tg(APPV717F)109Ili mutation (0 available)
Tg(GFAP-APOE_i2)14Hol mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:127846 )

• 66% of mice exhibit plaques after 18 months

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus but no the molecular layer of the dentate gyrus

• however, no fibrillar plaques are detected

homeostasis/metabolism

amyloid beta deposits ( J:127846 )

• 66% of mice exhibit plaques after 18 months

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus but no the molecular layer of the dentate gyrus

• however, no fibrillar plaques are detected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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