Phenotypes associated with this allele

• Allele Symbol: Kcnq1^tm3Kpfe
• Allele Name: targeted mutation 3, Karl Pfeifer
• Allele ID: MGI:3056651
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnq1^tm3Kpfe/Kcnq1^tm3Kpfe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3056759
ht2	Kcnq1^tm3Kpfe/Kcnq1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3056760

Genotype
MGI:3056759

hm1

• Allelic Composition: Kcnq1^tm3Kpfe/Kcnq1^tm3Kpfe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:93197 )

N • no behavioral abnormalities are seen

cardiovascular system

prolonged QT interval ( J:93197 )

• the QT interval is prolonged however the P- and QRS-waves are normal indicating that only repolarization is affected

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:93197 )

N • mutants are not deaf and have normal inner ear morphology

Genotype
MGI:3056760

ht2

• Allelic Composition: Kcnq1^tm3Kpfe/Kcnq1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

cardiovascular system

prolonged QT interval ( J:93197 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
long QT syndrome 1		DOID:0110644	OMIM:192500	J:93197