Phenotypes associated with this allele

• Allele Symbol: Crebbp^tm1.1Ltz
• Allele Name: targeted mutation 1.1, Beat Lutz
• Allele ID: MGI:3056562
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crebbp^tm1.1Ltz/Crebbp^tm1.1Ltz	involves: 129P2/OlaHsd * C57BL/6N	MGI:3057010
ht2	Crebbp^tm1.1Ltz/Crebbp^+	involves: 129P2/OlaHsd * C57BL/6N	MGI:3057012
ht3	Crebbp^tm1.1Ltz/Crebbp^+	involves: 129P2/OlaHsd * C57BL/6N * CD-1	MGI:3057013

Genotype
MGI:3057010

hm1

• Allelic Composition: Crebbp^tm1.1Ltz/Crebbp^tm1.1Ltz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:93192 )

Genotype
MGI:3057012

ht2

• Allelic Composition: Crebbp^tm1.1Ltz/Crebbp⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

mortality/aging

premature death ( J:93192 )

• reduced survival is seen and this allele could not be backcrossed into C57BL/6N, however backcrossing into CD-1 produces viable offspring

growth/size/body

decreased body size ( J:93192 )

• mutants are very small compared to wild-type littermates

nervous system

abnormal nervous system morphology ( J:93192 )

• neurological abnormalities are seen

Genotype
MGI:3057013

ht3

• Allelic Composition: Crebbp^tm1.1Ltz/Crebbp⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * CD-1

mortality/aging

premature death ( J:93192 )

• reduced survival is seen and this allele could not be backcrossed into C57BL/6N, however backcrossing into CD-1 produces viable offspring