Phenotypes associated with this allele

• Allele Symbol: Foxf2^W174R
• Allele Name: Trp174Arg
• Allele ID: MGI:3056482
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxf2^W174R/Foxf2^W174R	involves: BALB/c * C3H/HeH	MGI:3717735
ht2	Foxf2^W174R/Foxf2^+	involves: BALB/c * C3H/HeH	MGI:5297593

Genotype
MGI:3717735

hm1

• Allelic Composition: Foxf2^W174R/Foxf2^W174R
• Genetic Background: involves: BALB/c * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Foxf2^W174R/Foxf2^W174R pups are smaller at 3 days after birth and consume less milk at birth

mortality/aging

postnatal lethality, complete penetrance ( J:178103 )

• mice die within 14 days of birth

vision/eye

absent ciliary body ( J:178103 )

• formation of the ciliary body is absent in the E18.5 eye

abnormal eye development ( J:178103 )

• at E18.5, mice fail to exhibit evagination of tissue from the anterior optic cup unlike in wild-type mice

growth/size/body

decreased body size ( J:178103 )

• by P3

postnatal growth retardation ( J:178103 )

• mice fail to thrive after birth

craniofacial

craniofacial phenotype ( J:178103 )

N • mice exhibit normal primary and secondary palate

Genotype
MGI:5297593

ht2

• Allelic Composition: Foxf2^W174R/Foxf2⁺
• Genetic Background: involves: BALB/c * C3H/HeH

Iris abnormalities in Foxf2^W174R/Foxf2⁺ mice

vision/eye

abnormal eye morphology ( J:178103 )

• mice exhibit extraneous amorphous tissue between the retina and the lens unlike in wild-type mice

optic nerve swelling ( J:178103 )

• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina

abnormal anterior eye segment morphology ( J:178103 )

abnormal ciliary muscle morphology ( J:178103 )

• one mouse exhibits hypoplastic ciliary muscle compared with wild-type mice

abnormal iridocorneal angle ( J:178103 )

• 6 of 10 mice exhibit reduced angle between cornea and iris compared with wild-type mice

abnormal canal of Schlemm morphology ( J:178103 )

• smaller in 7 of 10 mice

absent Schlemm's canal ( J:178103 )

• absent in 2 of 10 mice

hypoplastic trabecular meshwork ( J:178103 )

• in 7 of 10 mice

abnormal ciliary process morphology ( J:178103 )

• hypoplastic ciliary body or ciliary body process

ciliary body hypoplasia ( J:178103 )

• hypoplastic ciliary body or ciliary body process

abnormal iris stroma morphology ( J:178103 )

• the iris stroma sows irregular thinning of the tissue and loss of structural organization at P45

anterior iris synechia ( J:178103 )

• iridocorneal adhesion is present

exophthalmos ( J:178103 )

• in two mice at 6 months of age

abnormal retina outer nuclear layer morphology ( J:178103 )

• disrupted in 2 of 18 mice due to swelling of the optic nerve

nervous system

optic nerve swelling ( J:178103 )

• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina

homeostasis/metabolism

optic nerve swelling ( J:178103 )

• 2 of 18 mice exhibit swelling of the optic nerve, which disrupts the outer nuclear layer of the retina

muscle

abnormal ciliary muscle morphology ( J:178103 )

• one mouse exhibits hypoplastic ciliary muscle compared with wild-type mice