Phenotypes associated with this allele

• Allele Symbol: Ago2^tm1Ghan
• Allele Name: targeted mutation 1, Greggory J Hannon
• Allele ID: MGI:3056454
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ago2^tm1Ghan/Ago2^tm1Ghan	involves: C57BL/6	MGI:3056684

Genotype
MGI:3056684

hm1

• Allelic Composition: Ago2^tm1Ghan/Ago2^tm1Ghan
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:93081 )

• embryos die of apparent heart failure

cardiovascular system

enlarged heart ( J:93081 )

• at E9.5 the heart is enlarged

pericardial edema ( J:93081 )

• the pericardium is swollen at E9.5

embryo

embryonic growth retardation ( J:93081 )

• at E10.5 embryos are severely developmentally delayed

open neural tube ( J:93081 )

• a defect in neural tube closure is seen at E9.5

wavy neural tube ( J:93081 )

• the caudal region of the neural tube is often wavy at E9.5

abnormal placenta morphology ( J:93081 )

abnormal visceral yolk sac morphology ( J:93081 )

nervous system

open neural tube ( J:93081 )

• a defect in neural tube closure is seen at E9.5

wavy neural tube ( J:93081 )

• the caudal region of the neural tube is often wavy at E9.5

abnormal forebrain development ( J:93081 )

• mispatterning of the anterior structures of the forebrain is seen at E9.5

growth/size/body

enlarged heart ( J:93081 )

• at E9.5 the heart is enlarged

embryonic growth retardation ( J:93081 )

• at E10.5 embryos are severely developmentally delayed

homeostasis/metabolism

pericardial edema ( J:93081 )

• the pericardium is swollen at E9.5