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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SV)427Bri
transgene insertion 427, Ralph L Brinster
MGI:3056377
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(SV)427Bri/0 C57BL/6J-Tg(SV)427Bri MGI:3839124


Genotype
MGI:3839124
tg1
Allelic
Composition		 Tg(SV)427Bri/0
Genetic
Background		 C57BL/6J-Tg(SV)427Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SV)427Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:79096 , J:147031 )
• mice die by 5 months of age (J:79096)
• mice die at 7 months of age (J:147031)

reproductive system
reduced male fertility ( J:79096 )
• only 2 of 42 mice are fertile

neoplasm
increased brain tumor incidence ( J:79096 , J:147031 )
• choroid plexus papillomas or carcinomas (J:79096)
• choroids plexus papillomas (J:147031)

cardiovascular system
intracranial hemorrhage ( J:79096 )
• on the cerebral surface

craniofacial
abnormal cranium morphology ( J:79096 )
• mice exhibit a cranium bulge unlike wild-type mice

immune system

nervous system
intracranial hemorrhage ( J:79096 )
• on the cerebral surface
increased brain tumor incidence ( J:79096 , J:147031 )
• choroid plexus papillomas or carcinomas (J:79096)
• choroids plexus papillomas (J:147031)

skeleton
abnormal cranium morphology ( J:79096 )
• mice exhibit a cranium bulge unlike wild-type mice

hematopoietic system

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory