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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wwtr1+
wild type
MGI:3056301
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Wwtr1tm1Hku/Wwtr1+ B6.Cg-Wwtr1tm1Hku MGI:4888219
cn2
 		Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * FVB/N MGI:5544297


Genotype
MGI:4888219
ht1
Allelic
Composition		 Wwtr1tm1Hku/Wwtr1+
Genetic
Background		 B6.Cg-Wwtr1tm1Hku
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wwtr1tm1Hku mutation (0 available); any Wwtr1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:164957 )
• at 9-10 wks of age, bleomycin-treated heterozygotes show only faint alveolitis and develop a significantly milder lung fibrosis, as evidenced by a low Ashcroft score, a significantly reduced lung hydroxyproline content, and decreased lung elastance relative to similarly-treated wild-type controls




Genotype
MGI:5544297
cn2
Allelic
Composition		 Wwtr1tm1.1Eno/Wwtr1+
Yap1tm1.1Eno/Yap1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-cre)2182Mds mutation (3 available)
Wwtr1tm1.1Eno mutation (0 available); any Wwtr1 mutation (26 available)
Yap1tm1.1Eno mutation (0 available); any Yap1 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cardiomyopathy in Wwtr1tm1.2Eno/Wwtr1+ Yap1tm1.1Eno/Yap1tm1.1Eno Tg(Myh6-cre)2182Mds/0 mice

mortality/aging
postnatal lethality, complete penetrance ( J:200670 )
• die by 10 days of age
• lethality is accelerated compared to mutant mice wild type for Wwtr1

cardiovascular system
myocardium hypoplasia ( J:200670 )
• about a 60% decrease in the number of cardiomyocytes

cellular

muscle
myocardium hypoplasia ( J:200670 )
• about a 60% decrease in the number of cardiomyocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory