Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-NFATC4)#Eno
• Allele Name: transgene insertion, Eric N Olson
• Allele ID: MGI:3056187
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Tg(Myh6-NFATC4)#Eno/?	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB	MGI:3836583
tg2	Tg(Myh6-NFATC4)#Eno/0	involves: FVB	MGI:3056190

Genotype
MGI:3836583

cx1

• Allelic Composition: Nfatc3^tm1Glm/Nfatc3^tm1Glm; Nfatc4^tm1Jmk/Nfatc4^tm1Jmk; Tg(Myh6-NFATC4)#Eno/?
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:84138 )

• viability extended to around E12

• no live embryos at E12.5 or later

cardiovascular system

cardiovascular system phenotype ( J:84138 )

N • normal heart phenotype at E11.5

N • heart mitochondrial respiration normal at E10.5

N • 70% of mitochondria are normal in heart muscle at E10.5

Genotype
MGI:3056190

tg2

• Allelic Composition: Tg(Myh6-NFATC4)#Eno/0
• Genetic Background: involves: FVB

cardiovascular system

myocardial fiber disarray ( J:93176 )

• myofiber disarray is seen

cardiac hypertrophy ( J:93176 )

• concentric hypertrophy is seen in both ventricles

cardiac fibrosis ( J:93176 )

growth/size/body

cardiac hypertrophy ( J:93176 )

• concentric hypertrophy is seen in both ventricles

muscle

myocardial fiber disarray ( J:93176 )

• myofiber disarray is seen