All Phenotypes Etv6<tm2.1Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Etv6^tm2.1Sho
targeted mutation 2.1, Stuart H Orkin
MGI:3056143

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^tm2.1Sho/Etv6^tm2.1Sho	involves: 129S1/Sv	MGI:3056261

Allelic Composition	Etv6^tm2.1Sho/Etv6^tm2.1Sho
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^tm2.1Sho mutation (0 available); any Etv6 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• about 95% of embryos died by E11

• embryos surviving past E11 were superficially normal at E18.5 but still not born alive

embryo

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11

hematopoietic system

abnormal erythropoiesis ( J:93052 )

• mice surviving past E11 with normal fetal liver hematopoiesis

• markedly reduced bone marrow hematopoiesis

cardiovascular system

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24