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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctnnb1tm1Yy
targeted mutation 1, Yingzi Yang
MGI:3056113
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ctnnb1tm1Yy/Ctnnb1tm1Yy
Twist2tm1(cre)Dor/Twist2+ 		involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:3056292
cn2
 		Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Col2a1-cre)1Bhr/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:3056288
cn3
 		Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prnp-GFP/cre)1Blw/0 		involves: 129S6/SvEvTac * C57BL/6 MGI:3056291
cn4
 		Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3687747
cn5
 		Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3687748
cn6
 		Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prrx1-cre)1Cjt/0 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:5426940


Genotype
MGI:3056292
cn1
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1Yy
Twist2tm1(cre)Dor/Twist2+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
fused synovial joints ( J:93028 )
• fused joints are seen in the elbow, hip, knee, ankle, and digit regions




Genotype
MGI:3056288
cn2
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:93028 )
• mutants die shortly after birth

craniofacial

limbs/digits/tail

skeleton
fused synovial joints ( J:93028 )
• the calcaneus is fused to the cuboid and the navicular is partially fused to the intermediate cuneiforms at E15.5




Genotype
MGI:3056291
cn3
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prnp-GFP/cre)1Blw/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Prnp-GFP/cre)1Blw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:93028 )
• mutants die shortly after birth

craniofacial

limbs/digits/tail

skeleton
fused synovial joints ( J:93028 )
• the calcaneus is fused to the cuboid and the navicular is partially fused to the intermediate cuneiforms at E15.5




Genotype
MGI:3687747
cn4
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ptch1tm1.1Yy mutation (0 available); any Ptch1 mutation (115 available)
Ptch1tm1Yy mutation (0 available); any Ptch1 mutation (115 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
arrested osteoblast differentiation ( J:112462 )
• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs

skeleton
arrested osteoblast differentiation ( J:112462 )
• osteoblast differentiation is severely blocked and mature osteoblasts are almost completely absent in E16.5 embryo limbs
abnormal elbow joint morphology ( J:112462 )
• the elbow joint interzone fails to form
abnormal long bone hypertrophic chondrocyte zone ( J:112462 )
• chondrocyte hypertrophy is inhibited
fused synovial joints ( J:112462 )
• show extensive synovial joint fusions which are much more severe than in each of the single mutants
abnormal perichondrium morphology ( J:112462 )
• perichondrium is thinner
decreased bone mineralization ( J:112462 )
• mineralization in the long bones is more severely reduced than in single conditional Ctnnb1 mutants
delayed endochondral bone ossification ( J:112462 )
• ossification is more severely inhibited than in single conditional Ctnnb1 mutants

craniofacial
craniofacial phenotype ( J:112462 )
N
• exhibit normal posterior skull formation

limbs/digits/tail
abnormal elbow joint morphology ( J:112462 )
• the elbow joint interzone fails to form




Genotype
MGI:3687748
cn5
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased chondrocyte apoptosis ( J:112462 )
• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5

skeleton
increased chondrocyte apoptosis ( J:112462 )
• exhibit extensive cell death in both proliferative and resting chondrocytes at E18.5
abnormal perichondrium morphology ( J:112462 )
• perichondrium is thinner
decreased bone mineralization ( J:112462 )
• mineralization is decreased
failure of bone ossification ( J:112462 )
• ossification is inhibited




Genotype
MGI:5426940
cn6
Allelic
Composition		 Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Yy mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal limb development ( J:184918 )
• authors state that mice exhibit the same defects as in Wlstm1Xzg/Wlstm1Xzg Tg(Msx2-cre)5Rem mice

integument
abnormal hair follicle development ( J:184918 )
• loss of hair follicles in the dorsal dermis of the limb

muscle
abnormal tendon morphology ( J:184918 )
• in the forelimbs at E17.5

skeleton
abnormal tendon morphology ( J:184918 )
• in the forelimbs at E17.5
abnormal ligament morphology ( J:184918 )
• in the forelimbs at E17.5

pigmentation
abnormal melanogenesis ( J:184918 )
• loss of melanogenesis in the dorsal dermis of the limb




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory