All Phenotypes Hdac5<tm1Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hdac5^tm1Eno
targeted mutation 1, Eric N Olson
MGI:3056065

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdac5^tm1Eno/Hdac5^tm1Eno	involves: 129S2/SvPas	MGI:4418123
hm2	Hdac5^tm1Eno/Hdac5^tm1Eno	involves: 129S2/SvPas * C57BL/6	MGI:3056192
cn3	Hdac4^tm1Eno/Hdac4^tm2.1Eno Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myog-cre)1Eno/0	involves: 129 * 129S/SvEv * 129S2/SvPas	MGI:4418137
cx4	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:4418139
cx5	Hdac5^tm1Eno/Hdac5^tm1Eno Pkd2^tm2Som/Pkd2^tm2Som	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:4440913
cx6	Hdac5^tm1Eno/Hdac5⁺ Pkd2^tm2Som/Pkd2^tm2Som	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL	MGI:4440917
cx7	Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9^tm1Eno	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3056194
cx8	Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myh6-Camta2)1Eno/0	involves: 129S2/SvPas	MGI:3696715
cx9	Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myh6-Ppp3ca)37Eno/0	involves: 129S2/SvPas * C57BL/6	MGI:3056193

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:127416 )

N	• no change in the abundance of slow fibers

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:93021 )

• by 8 months of age mutant hearts are 20% larger than wild-type due to hypertrophy

• the hypertrophic response induced by increased afterload is increased in mutants compared to wild-type mice

growth/size/body

cardiac hypertrophy ( J:93021 )

• by 8 months of age mutant hearts are 20% larger than wild-type due to hypertrophy

• the hypertrophic response induced by increased afterload is increased in mutants compared to wild-type mice

Allelic Composition	Hdac4^tm1Eno/Hdac4^tm2.1Eno Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myog-cre)1Eno/0
Genetic Background	involves: 129 * 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac4^tm2.1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Tg(Myog-cre)1Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• soleus muscles show an increase in the percentage of slow myofibers

Allelic Composition	Hdac4^tm1Eno/Hdac4⁺ Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9⁺
Genetic Background	involves: 129 * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac4^tm1Eno mutation (0 available); any Hdac4 mutation (110 available)
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• increase in slow fibers

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno Pkd2^tm2Som/Pkd2^tm2Som
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Pkd2^tm2Som mutation (0 available); any Pkd2 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:158762 )

• only 1 mouse is present at E18.5

Allelic Composition	Hdac5^tm1Eno/Hdac5⁺ Pkd2^tm2Som/Pkd2^tm2Som
Genetic Background	involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

kidney cyst ( J:158762 )

• mice exhibit reduced kidney cyst formation compared with Pkd2^tm2Som homozygotes

growth/size/body

kidney cyst ( J:158762 )

• mice exhibit reduced kidney cyst formation compared with Pkd2^tm2Som homozygotes

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno Hdac9^tm1Eno/Hdac9^tm1Eno
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Hdac9^tm1Eno mutation (0 available); any Hdac9 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:93021 )

• double homozygous embryos begin to die around E15.5 with only about 12% of double homozygotes surviving to adulthood

cardiovascular system

ventricular septal defect ( J:93021 )

• at E15.5 ventricular septal defects were seen in 77% of double homozygous embryos often associated with hemorrhages

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

thin ventricular wall ( J:93021 )

• at E15.5 thin ventricular walls were seen in 20% of double homozygous embryos often associated with hemorrhages

hemorrhage ( J:93021 )

• hemorrhages are seen throughout the body of some mutant embryos at E15.5

growth/size/body

cardiac hypertrophy ( J:93021 )

• 1 month old mutant heart to body weight ratios are increased and markers of cardiac hypertrophy are upregulated

postnatal growth retardation ( J:93021 )

• severe growth retardation is seen with surviving adults weighing 1/3 as much as wild-type mice

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• soleus muscles show an increase in the percentage of slow myofibers

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myh6-Camta2)1Eno/0
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Tg(Myh6-Camta2)1Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:115868 )

• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice

growth/size/body

cardiac hypertrophy ( J:115868 )

• exhibit even more enhanced cardiac hypertrophy (twice the amount) than single transgenic Tg(Myh6-Camta2)1Eno mice

Allelic Composition	Hdac5^tm1Eno/Hdac5^tm1Eno Tg(Myh6-Ppp3ca)37Eno/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac5^tm1Eno mutation (0 available); any Hdac5 mutation (56 available)
Tg(Myh6-Ppp3ca)37Eno mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:93021 )

• transgenic mice are highly susceptible to sudden death from heart failure with none surviving beyond 8 weeks of age

postnatal lethality, complete penetrance ( J:93021 )

cardiovascular system

cardiac hypertrophy ( J:93021 )

• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy

growth/size/body

cardiac hypertrophy ( J:93021 )

• by 4 weeks of age mutant hearts are 3-fold larger than wild-type due to hypertrophy

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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