Phenotypes associated with this allele

• Allele Symbol: Brca2^tm1Mhun
• Allele Name: targeted mutation 1, MC Hung
• Allele ID: MGI:3055613
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brca2^tm1Mhun/Brca2^tm1Mhun	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3055717
ht2	Brca2^tm1Mhun/Brca2^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3055719

Genotype
MGI:3055717

hm1

• Allelic Composition: Brca2^tm1Mhun/Brca2^tm1Mhun
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89083 )

• homozygotes died between E8.5 and E9.5

Genotype
MGI:3055719

ht2

• Allelic Composition: Brca2^tm1Mhun/Brca2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

neoplasm

decreased tumor incidence ( J:89083 )

• remain tumor free for over a year

decreased incidence of tumors by chemical induction ( J:89083 )

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

cellular

abnormal cell physiology ( J:89083 )

• mammary tumor cell lines grew significantly faster after the third day in culture

increased apoptosis ( J:89083 )

• very sensitive to DMBA induced apoptosis

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:89083 )

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:89083