All Phenotypes Myf5<tm1Tajb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf5^tm1Tajb
targeted mutation 1, Shahragim Tajbakhsh
MGI:3055340

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm1Tajb/Myf5^tm1Tajb	involves: 129S2/SvPas	MGI:3850157
hm2	Myf5^tm1Tajb/Myf5^tm1Tajb	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055416
cx3	Myf5^tm1Tajb/Myf5^tm1Tajb Pax7^tm1.1Tajb/Pax7^tm1.1Tajb	involves: 129S2/SvPas	MGI:3850159
cx4	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055418

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is absent in some mice and severely reduced compared to in wild-type mice

vision/eye

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is absent in some mice and severely reduced compared to in wild-type mice

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

absent myotome ( J:92799 )

• at E10 early myotome is missing

abnormal skeletal muscle morphology ( J:92799 )

• dorsal muscles are absent

cellular

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb Pax7^tm1.1Tajb/Pax7^tm1.1Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (17 available)
Pax7^tm1.1Tajb mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:150130 )

N	• pharyngeal arch-derived muscles are present

abnormal extraocular muscle morphology ( J:150130 )

• compared to in Myf5^tm1Tajb homozygotes

vision/eye

abnormal extraocular muscle morphology ( J:150130 )

• compared to in Myf5^tm1Tajb homozygotes

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (17 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• only the double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth

absent skeletal muscle ( J:92799 )

• mutants essentially lack skeletal muscle throughout the body including the head

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23