All Phenotypes Myf5<tm1Tajb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf5^tm1Tajb
targeted mutation 1, Shahragim Tajbakhsh
MGI:3055340

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm1Tajb/Myf5^tm1Tajb	involves: 129S2/SvPas	MGI:3850157
hm2	Myf5^tm1Tajb/Myf5^tm1Tajb	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055416
cx3	Myf5^tm1Tajb/Myf5^tm1Tajb Pax7^tm1.1Tajb/Pax7^tm1.1Tajb	involves: 129S2/SvPas	MGI:3850159
cx4	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3055418

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is absent in some mice and severely reduced compared to in wild-type mice

vision/eye

abnormal eye muscle development ( J:150130 )

• the extraocular muscle anlage is absent in some mice and severely reduced compared to in wild-type mice

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

absent myotome ( J:92799 )

• at E10 early myotome is missing

abnormal skeletal muscle morphology ( J:92799 )

• dorsal muscles are absent

cellular

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb Pax7^tm1.1Tajb/Pax7^tm1.1Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (18 available)
Pax7^tm1.1Tajb mutation (0 available); any Pax7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:150130 )

N	• pharyngeal arch-derived muscles are present

abnormal extraocular muscle morphology ( J:150130 )

• compared to in Myf5^tm1Tajb homozygotes

vision/eye

abnormal extraocular muscle morphology ( J:150130 )

• compared to in Myf5^tm1Tajb homozygotes

Allelic Composition	Myf5^tm1Tajb/Myf5^tm1Tajb Myod1^tm1Jae/Myod1^tm1Jae
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1Tajb mutation (0 available); any Myf5 mutation (18 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• only the double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• skeletal muscle differentiation is seen at E12.5 however myogenesis is still severely impaired such that mutants essentially lack skeletal muscle at birth

absent skeletal muscle ( J:92799 )

• mutants essentially lack skeletal muscle throughout the body including the head

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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