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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp4tm1Eem
targeted mutation 1, Edward E Morrisey
MGI:3055161
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxp4tm1Eem/Foxp4tm1Eem involves: 129S1/Sv * 129X1/SvJ MGI:5440706
hm2
 		Foxp4tm1Eem/Foxp4tm1Eem involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3055177
ht3
 		Foxp4Gt(RRF116)Byg/Foxp4tm1Eem involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:5440702


Genotype
MGI:5440706
hm1
Allelic
Composition		 Foxp4tm1Eem/Foxp4tm1Eem
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4tm1Eem mutation (0 available); any Foxp4 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:188384 )
• authors state that mice exhibit the same neural tube defects as in Foxp4Gt(RRF116)Byg homozygotes at a lower frequency

nervous system
abnormal neural tube morphology ( J:188384 )
• authors state that mice exhibit the same neural tube defects as in Foxp4Gt(RRF116)Byg homozygotes at a lower frequency




Genotype
MGI:3055177
hm2
Allelic
Composition		 Foxp4tm1Eem/Foxp4tm1Eem
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4tm1Eem mutation (0 available); any Foxp4 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal heart morphology ( J:92817 )
• development of two complete hearts apparent by E8.5
• both structurally normal
cardia bifida ( J:92817 )
• no bilateral heart tube fusion although looping morphogenesis was normal
abnormal heart position or orientation ( J:92817 )
• two hearts were located bilaterally
abnormal cardiovascular system physiology ( J:92817 )
• normal heart rate for both hearts but heart beats were asynchronous

digestive/alimentary system
abnormal digestive system development ( J:92817 )
• failure of the foregut to close before E11.5
tracheoesophageal fistula ( J:92817 )
• failure of the foregut to divide into trachea and esophagus
• lungs and liver do develop however

respiratory system
tracheoesophageal fistula ( J:92817 )
• failure of the foregut to divide into trachea and esophagus
• lungs and liver do develop however




Genotype
MGI:5440702
ht3
Allelic
Composition		 Foxp4Gt(RRF116)Byg/Foxp4tm1Eem
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp4Gt(RRF116)Byg mutation (0 available); any Foxp4 mutation (91 available)
Foxp4tm1Eem mutation (0 available); any Foxp4 mutation (91 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:188384 )
• authors state that mice exhibit the same neural tube defects as in Foxp4Gt(RRF116)Byg homozygotes at a higher frequency likely due to increased survival

embryo
abnormal neural tube morphology ( J:188384 )
• authors state that mice exhibit the same neural tube defects as in Foxp4Gt(RRF116)Byg homozygotes at a higher frequency likely due to increased survival




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory