Phenotypes associated with this allele

• Allele Symbol: Cd22^tm2Tft
• Allele Name: targeted mutation 2, Thomas F Tedder
• Allele ID: MGI:3054883
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd22^tm2Tft/Cd22^tm2Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5582906
hm2	Cd22^tm2Tft/Cd22^tm2Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3055136
cx3	Cd22^tm2Tft/Cd22^tm2Tft Endou^tm1Tft/Endou^tm1Tft	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5582907

Genotype
MGI:5582906

hm1

• Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

decreased B cell number ( J:208364 )

• in the spleen

abnormal peripheral B cell anergy ( J:208364 )

• in the spleen

cellular

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

hematopoietic system

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

decreased B cell number ( J:208364 )

• in the spleen

Genotype
MGI:3055136

hm2

• Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

hematopoietic system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

Genotype
MGI:5582907

cx3

• Allelic Composition: Cd22^tm2Tft/Cd22^tm2Tft; Endou^tm1Tft/Endou^tm1Tft
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

immune system

immune system phenotype ( J:208364 )

N • splenic B cell numbers are restored and reversed activation-induced B cell apoptosis with normal BCR-induced blast development and proliferation compared to in Cd22^tm2Tft homozygotes

N • the splenic B cell anergy phenotype observed in Cd22^tm2Tft homozygotes is rescued