All Phenotypes Cd22<tm2Tft> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd22^tm2Tft/Cd22^tm2Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5582906
hm2	Cd22^tm2Tft/Cd22^tm2Tft	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3055136
cx3	Cd22^tm2Tft/Cd22^tm2Tft Endou^tm1Tft/Endou^tm1Tft	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5582907

Allelic Composition	Cd22^tm2Tft/Cd22^tm2Tft
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm2Tft mutation (1 available); any Cd22 mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

decreased B cell number ( J:208364 )

• in the spleen

abnormal peripheral B cell anergy ( J:208364 )

• in the spleen

cellular

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

hematopoietic system

increased activation-induced B cell apoptosis ( J:208364 )

decreased B cell proliferation ( J:208364 )

• of stimulated cells

decreased B cell number ( J:208364 )

• in the spleen

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

immune system

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

decreased B cell number ( J:92736 )

• the percentage of mature recirculating B cells, B cells in the blood, and marginal zone B cells are reduced however the number of B cells in the lymph nodes is increased

cellular

decreased B cell proliferation ( J:92736 )

• B cell receptor induced proliferation is reduced over a range of anti-IgM concentrations compared to wild-type B cells

increased B cell proliferation ( J:92736 )

• B cell hyperproliferation is seen in response to a mAb to CD40

• B cell turnover is increased in all tissues

Allelic Composition	Cd22^tm2Tft/Cd22^tm2Tft Endou^tm1Tft/Endou^tm1Tft
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22^tm2Tft mutation (1 available); any Cd22 mutation (63 available)
Endou^tm1Tft mutation (0 available); any Endou mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:208364 )

N	• splenic B cell numbers are restored and reversed activation-induced B cell apoptosis with normal BCR-induced blast development and proliferation compared to in Cd22^tm2Tft homozygotes • the splenic B cell anergy phenotype observed in Cd22^tm2Tft homozygotes is rescued

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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