Phenotypes associated with this allele

• Allele Symbol: Tnfrsf13c^tm1Msc
• Allele Name: targeted mutation 1, Martin L Scott
• Allele ID: MGI:3054873
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf13c^tm1Msc/Tnfrsf13c^tm1Msc	involves: 129P2/OlaHsd * C57BL/6	MGI:3055019

Genotype
MGI:3055019

hm1

• Allelic Composition: Tnfrsf13c^tm1Msc/Tnfrsf13c^tm1Msc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:92676 )

• severe reduction of mature B cells in lymph nodes, peripheral blood and bone marrow

• severe loss of the IgDhigh IgMlow mature population in spleen

• total number of B220+ (Ptprc) cells reduced 5 fold in spleen

absent transitional stage B cells ( J:92676 )

• B cell loss in transitional type 2 (IgDhigh IgMhigh) and MZB/transitional type 1 (IgDint IgMhigh) populations

decreased B-2 B cell number ( J:92676 )

• peritoneal B2 cell population reduced

absent marginal zone B cells ( J:92676 )

• loss of marginal zone B cells in spleen

decreased IgD level ( J:92676 )

decreased IgG level ( J:92676 )

• reduced level of IgG in response to T cell dependent challenge with keyhole limpet hemocyanin and chicken gamma globulin

decreased IgG1 level ( J:92676 )

• reduced serum levels of IgG1

decreased IgM level ( J:92676 )

immune system

decreased B cell number ( J:92676 )

• severe reduction of mature B cells in lymph nodes, peripheral blood and bone marrow

• severe loss of the IgDhigh IgMlow mature population in spleen

• total number of B220+ (Ptprc) cells reduced 5 fold in spleen

absent transitional stage B cells ( J:92676 )

• B cell loss in transitional type 2 (IgDhigh IgMhigh) and MZB/transitional type 1 (IgDint IgMhigh) populations

decreased B-2 B cell number ( J:92676 )

• peritoneal B2 cell population reduced

absent marginal zone B cells ( J:92676 )

• loss of marginal zone B cells in spleen

abnormal humoral immune response ( J:92676 )

• cannot carry out T cell-dependent Ab formation

decreased IgD level ( J:92676 )

decreased IgG level ( J:92676 )

• reduced level of IgG in response to T cell dependent challenge with keyhole limpet hemocyanin and chicken gamma globulin

decreased IgG1 level ( J:92676 )

• reduced serum levels of IgG1

decreased IgM level ( J:92676 )