All Phenotypes Npas3<tm1Slm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Npas3^tm1Slm
targeted mutation 1, Steven l McKnight
MGI:3054783

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npas3^tm1Slm/Npas3^tm1Slm	involves: 129S/SvEv * C57BL/6	MGI:3054794
cx2	Npas1^tm1Slm/Npas1^tm1Slm Npas3^tm1Slm/Npas3^tm1Slm	involves: 129S6/SvEvTac * C57BL/6	MGI:3054795
cx3	Npas1^tm1Slm/Npas1⁺ Npas3^tm1Slm/Npas3^tm1Slm	involves: 129S6/SvEvTac * C57BL/6	MGI:3054800

Allelic Composition	Npas3^tm1Slm/Npas3^tm1Slm
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npas3^tm1Slm mutation (1 available); any Npas3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

short stride length ( J:92610 )

• a short and irregular stride length is seen

hyperactivity ( J:92610 )

• increased activity is seen in an open field test mostly in the outer rim of the test field

stereotypic behavior ( J:92610 )

• mutants display a stereotypic darting behavior

abnormal maternal nurturing ( J:92610 )

• females fail to properly nest and mother their litters resulting in death of the pups by about 48 hours after birth

abnormal social investigation ( J:92610 )

• mutants show a deficit in learned familiarization with no drop in interactions following reintroduction to a previously encountered individual

growth/size/body

decreased body size ( J:92610 )

• males and females are 20% smaller compared to wild-type mice

Allelic Composition	Npas1^tm1Slm/Npas1^tm1Slm Npas3^tm1Slm/Npas3^tm1Slm
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npas1^tm1Slm mutation (0 available); any Npas1 mutation (18 available)
Npas3^tm1Slm mutation (1 available); any Npas3 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal cued conditioning behavior ( J:92610 )

• instead of freezing in response to a stimulus previously coupled to a mild foot shock mutants display increased activity

short stride length ( J:92610 )

• a short and irregular stride length is seen

hyperactivity ( J:92610 )

• increased activity is seen in an open field test mostly in the outer rim of the test field

stereotypic behavior ( J:92610 )

• mutants display a stereotypic darting behavior

abnormal maternal nurturing ( J:92610 )

• females fail to properly nest and mother their litters resulting in death of the pups by about 48 hours after birth

abnormal social investigation ( J:92610 )

• mutants show a deficit in learned familiarization with no drop in interactions following reintroduction to a previously encountered individual

growth/size/body

decreased body size ( J:92610 )

• males and females are 20% smaller compared to wild-type mice

nervous system

abnormal prepulse inhibition ( J:92610 )

• a significant reduction in prepulse inhibition is seen

Allelic Composition	Npas1^tm1Slm/Npas1⁺ Npas3^tm1Slm/Npas3^tm1Slm
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

stereotypic behavior ( J:92610 )

• mutants display a stereotypic darting behavior

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