All Phenotypes Tg(WapMyc)212Bri MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(WapMyc)212Bri/0 Tg(WapTgfa)215Bri/0	involves: C57BL/6 * SJL	MGI:3800662
tg2	Tg(WapMyc)212Bri/0	FVB.Cg-Tg(WapMyc)212Bri	MGI:3800659
tg3	Tg(WapMyc)212Bri/0	involves: C57BL/6 * SJL	MGI:3800802

Allelic Composition	Tg(WapMyc)212Bri/0 Tg(WapTgfa)215Bri/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapMyc)212Bri mutation (1 available)
Tg(WapTgfa)215Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:56318 )

• female mice die at less than 4 months of age roughly 2 months after their first pregnancy

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:56318 )

• involution is abolished and only a mild decrease in alveolar size is observed postparturition

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

mammary gland hyperplasia ( J:56318 )

• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes

abnormal lactation ( J:56318 )

• female mice do not lactate

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

integument

abnormal involution of the mammary gland ( J:56318 )

• involution is abolished and only a mild decrease in alveolar size is observed postparturition

increased mammary gland tumor incidence ( J:56318 )

• mice develop large mammary tumors with lung metastases in 2 of 7 mice regardless of pregnancy status and gender

• tumors are poorly differentiated with extensive hemorrhages, necrosis and codominant histology

• tumors are transplantable with shorter latency than tumors with only one of the transgenes expressing

mammary gland hyperplasia ( J:56318 )

• mice exhibit increased mammary gland hyperplasia compared to wild-type females or females carrying only one of the transgenes

abnormal lactation ( J:56318 )

• female mice do not lactate

Allelic Composition	Tg(WapMyc)212Bri/0
Genetic Background	FVB.Cg-Tg(WapMyc)212Bri

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(WapMyc)212Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:114568 )

• apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

• ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

• lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

• cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

• unlike wild-type mice, proliferation rates remain high as mice age

• mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

• cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands

neoplasm

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

integument

abnormal mammary gland morphology ( J:114568 )

• apoptosis in the mammary gland does not decrease with age

mammary gland duct hyperplasia ( J:114568 )

• ductal cell proliferation rates are higher than in wild-type mice but equivalent to lobule proliferation rates

abnormal mammary gland lobule morphology ( J:114568 )

• lobules contain more cells than in wild-type mice

increased mammary gland tumor incidence ( J:114568 )

• cell proliferation rates within tumors is greater than in hyperplastic mammary tissues

mammary gland hyperplasia ( J:114568 )

• cell proliferation within lobules is increased after 16 weeks of age compared to wild-type mice

• unlike wild-type mice, proliferation rates remain high as mice age

• mice exhibit increased number and size of hyperplastic areas compared to wild-type mice

• cell proliferation of normal cells in tumor containing glands is increased compared to non-tumor containing glands

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:56318 )

• female mice die by 8 months of age

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:56318 )

• female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

• female mice do not lactate

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

integument

mammary gland alveolar hyperplasia ( J:56318 )

• female mice exhibit enlarged and hyperplastic alveoli at day 14 of pregnancy with poorly differentiated epithelium and numerous dead cells

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 8 months of age

• female mice develop solid carcinomas and few glandular/microcystic or papillary adenocarcinomas

• 42% of tumors are mixed glandular and solid or glandular and papillary

• lung metastasis occurs in 3 of 14 mice and tumors are transplantable

• however, virgin females do not develop mammary gland tumors

increased mammary adenocarcinoma incidence ( J:56318 )

• few tumors are adenocarcinomas

lactation failure ( J:56318 )

• female mice do not lactate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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