Phenotypes associated with this allele

• Allele Symbol: Tg(Ctsk-cre)1Rda
• Allele Name: transgene insertion 1, Rachel A Davey
• Allele ID: MGI:3053818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fcgr4^tm1Rav/Fcgr4^tm1Rav Tg(Ctsk-cre)1Rda/0	involves: C57BL/6	MGI:5521480
cn2	Gt(ROSA)26Sor^tm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor^+ Tg(Ctsk-cre)1Rda/0	involves: C57BL/6	MGI:6159158

Genotype
MGI:5521480

cn1

• Allelic Composition: Fcgr4^tm1Rav/Fcgr4^tm1Rav; Tg(Ctsk-cre)1Rda/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:197378 )

N • normal osteoclastogenesis in the presence of FCGR4 cross-linking antibodies

decreased osteoclast cell number ( J:197378 )

arthritis ( J:197378 )

• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies

decreased bone resorption ( J:197378 )

• reduced bone erosion in the presence of FCGR4 cross-linking antibodies

homeostasis/metabolism

abnormal circulating protein level ( J:197378 )

• reduced serum collagen 1 fragments in the presence of FCGR4 cross-linking antibodies

immune system

decreased osteoclast cell number ( J:197378 )

arthritis ( J:197378 )

• no reduction in clinical signs of arthritis in the presence of FCGR4 cross-linking antibodies

hematopoietic system

decreased osteoclast cell number ( J:197378 )

Genotype
MGI:6159158

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Slc39a14*L438R)Wvh}/Gt(ROSA)26Sor⁺; Tg(Ctsk-cre)1Rda/0
• Genetic Background: involves: C57BL/6

skeleton

abnormal tibia morphology ( J:261326 )

♂ • tibia show a decrease in osteoclast-covered bone surface

♂ • however, osteoclast number and osteoblast-covered surface and number are unaltered

increased trabecular bone volume ( J:261326 )

♀ • trabecular bone volume is increased in lumbar spine of females

abnormal compact bone morphology ( J:261326 )

• males exhibit decreased cortical porosity in femurs while females exhibit increased cortical porosity in femurs

• however, trabecular bone is unaffected

increased bone trabecula number ( J:261326 )

♀ • trabecula number is increased in lumbar spine of females

decreased bone trabecular spacing ( J:261326 )

♀ • trabecular separation in lumbar spine of females is decreased

increased trabecular bone thickness ( J:261326 )

♀ • trabecular thickness is increased in lumbar spine of females

increased bone mineralization ( J:261326 )

♂ • tibial endocortical bone surface shows an increase in endosteal mineralizing surface

decreased bone ossification ( J:261326 )

♂ • trabecular bone surface of vertebral bodies shows a decrease in mineralizing surface and bone formation rate

♂ • however, biomechanical properties of femurs are similar to controls

limbs/digits/tail

abnormal tibia morphology ( J:261326 )

♂ • tibia show a decrease in osteoclast-covered bone surface

♂ • however, osteoclast number and osteoblast-covered surface and number are unaltered

craniofacial

craniofacial phenotype ( J:261326 )

♂N • mice exhibit normal calvarial bone thickness and porosity