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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Acp5-cre)4Rda
transgene insertion 4, Rachel A Davey
MGI:3053813
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Calcrtm1Rda/Calcrtm1Rda
Tg(Acp5-cre)4Rda/0 		B6.Cg-Calcrtm1Rda Tg(Acp5-cre)4Rda MGI:4353057
cn2
 		Scintm1Glog/Scintm1Glog
Tg(Acp5-cre)4Rda/0 		either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * CBA) MGI:5759798


Genotype
MGI:4353057
cn1
Allelic
Composition		 Calcrtm1Rda/Calcrtm1Rda
Tg(Acp5-cre)4Rda/0
Genetic
Background		 B6.Cg-Calcrtm1Rda Tg(Acp5-cre)4Rda
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcrtm1Rda mutation (2 available); any Calcr mutation (58 available)
Tg(Acp5-cre)4Rda mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:150982 )
• no pups with this genotype are born alive




Genotype
MGI:5759798
cn2
Allelic
Composition		 Scintm1Glog/Scintm1Glog
Tg(Acp5-cre)4Rda/0
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * CBA)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scintm1Glog mutation (0 available); any Scin mutation (63 available)
Tg(Acp5-cre)4Rda mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast morphology ( J:223220 )
• disorganized podosome-based actin filament superstructures compared with control cells
abnormal osteoclast differentiation ( J:223220 )
• reduced osteoclast formation compared with control mice
abnormal osteoclast physiology ( J:223220 )
• reduced dentin resorption compared with control osteoclasts
• impaired osteoclastic cell-cell fusion compared with control cells

homeostasis/metabolism
decreased susceptibility to injury ( J:223220 )
• following silk-biofilm ligature model to induce periodontal disease, mice exhibit less bone loss compared with control mice

cellular
abnormal osteoclast differentiation ( J:223220 )
• reduced osteoclast formation compared with control mice

hematopoietic system
abnormal osteoclast morphology ( J:223220 )
• disorganized podosome-based actin filament superstructures compared with control cells
abnormal osteoclast differentiation ( J:223220 )
• reduced osteoclast formation compared with control mice
abnormal osteoclast physiology ( J:223220 )
• reduced dentin resorption compared with control osteoclasts
• impaired osteoclastic cell-cell fusion compared with control cells

immune system
abnormal osteoclast morphology ( J:223220 )
• disorganized podosome-based actin filament superstructures compared with control cells
abnormal osteoclast differentiation ( J:223220 )
• reduced osteoclast formation compared with control mice
abnormal osteoclast physiology ( J:223220 )
• reduced dentin resorption compared with control osteoclasts
• impaired osteoclastic cell-cell fusion compared with control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory