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Allele Symbol Allele Name Allele ID |
Tg(ANX6)2Agh transgene insertion 2, Ann-Marie Gunteski-Hamblin MGI:3053801 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die prior to weaning
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• mice exhibit severe heart pathology and die prior to weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myocytes in the pulmonary vein muscular wall are replaced with fibrous tissue
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• mice exhibit dilation of the atria with large thrombi that partially occlude the lumen
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• mice exhibit mild heart lesions with multifocally extensive and diffuse fibrosis in the ventricles and atria that worsens with age
• mice exhibit occasional mineralization associated with fibrosis
• the myocardium and endocardium of the ventricles are most affected by fibrosis
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• mice exhibit an increase in chamber turbulence or pooling in the heart
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• cardiomyocytes exhibit decreased percent shortening, rate of contraction and rate of relaxation compared to wild-type mice
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• cardiomyocytes exhibit a 40% lower basal level of free calcium ions and after stimulation a lower calcium ion peak compared to in wild-type mice
• however, depression of base levels of intracellular calcium ions is normal following stimulation
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• heart function deteriorates with age
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• mice exhibit myocyte necrosis, mild inflammation and occasional mineralization associated with fibrosis
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• mice exhibit dilation of the atria with large thrombi that partially occlude the lumen
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• in some mice
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• mice exhibit myocyte necrosis, mild inflammation and occasional mineralization associated with fibrosis
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• in some mice
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• cardiomyocytes exhibit decreased percent shortening, rate of contraction and rate of relaxation compared to wild-type mice
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• heart function deteriorates with age
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• in some mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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