Phenotypes associated with this allele

• Allele Symbol: Sema4a^{Gt(OST393408)Lex}
• Allele Name: gene trap OST393408, Lexicon Genetics
• Allele ID: MGI:3052925
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema4a^Gt(OST393408)Lex/Sema4a^Gt(OST393408)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3052972

Genotype
MGI:3052972

hm1

• Allelic Composition: Sema4a^{Gt(OST393408)Lex}/Sema4a^{Gt(OST393408)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

abnormal retina pigment epithelium morphology ( J:92305 )

• abnormal interface between apical microvilli and outer segments

decreased eye pigmentation ( J:92305 )

• depigmentation by 14 weeks

vision/eye

abnormal eye morphology ( J:92305 )

decreased retina photoreceptor cell number ( J:92305 )

• substantial decrease in photoreceptors by three weeks of age

abnormal photoreceptor outer segment morphology ( J:92305 )

• outer segments appear as whorls without proper orientation to retinal pigment epithelium layer by day 14

abnormal retina cone cell outer segment morphology ( J:92305 )

• cones fail to form elongated outer segments during the second postnatal week

abnormal retina rod cell outer segment morphology ( J:92305 )

• rods fail to form elongated outer segments during the second postnatal week

abnormal retina pigment epithelium morphology ( J:92305 )

• abnormal interface between apical microvilli and outer segments

decreased eye pigmentation ( J:92305 )

• depigmentation by 14 weeks

thin retina inner nuclear layer ( J:92305 )

• inner nuclear layer thinned by one year of age

thin retina inner plexiform layer ( J:92305 )

• inner plexiform layer thinned by one year of age

thin retina outer nuclear layer ( J:92305 )

• outer nuclear layer reduced to a single row of photoreceptors by 14 weeks

retina degeneration ( J:92305 )

• severe retinal degeneration by 14 weeks

abnormal eye physiology ( J:92305 )

abnormal eye electrophysiology ( J:92305 )

• lack of response to electroretinography

nervous system

decreased retina photoreceptor cell number ( J:92305 )

• substantial decrease in photoreceptors by three weeks of age

abnormal photoreceptor outer segment morphology ( J:92305 )

• outer segments appear as whorls without proper orientation to retinal pigment epithelium layer by day 14

abnormal retina cone cell outer segment morphology ( J:92305 )

• cones fail to form elongated outer segments during the second postnatal week

abnormal retina rod cell outer segment morphology ( J:92305 )

• rods fail to form elongated outer segments during the second postnatal week