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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Mt1)174Bri
transgene insertion 174, Ralph L Brinster
MGI:3052794
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
Tg(Mt1)174Bri/0 		involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL MGI:4361575
tg2
 		Tg(Mt1)174Bri/Tg(Mt1)174Bri involves: C57BL/6 * SJL MGI:3798856
tg3
 		Tg(Mt1)174Bri/0 B6.Cg-Tg(Mt1)174Bri/J MGI:4361627
tg4
 		Tg(Mt1)174Bri/0 involves: C57BL/6 * SJL MGI:3798838


Genotype
MGI:4361575
cx1
Allelic
Composition		 Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
Tg(Mt1)174Bri/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-brJ mutation (0 available); any Atp7a mutation (69 available)
Mt1tm1Bri mutation (1 available); any Mt1 mutation (49 available)
Mt2tm1Bri mutation (1 available); any Mt2 mutation (8 available)
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:33276 )
• mice are phenotypically normal




Genotype
MGI:3798856
tg2
Allelic
Composition		 Tg(Mt1)174Bri/Tg(Mt1)174Bri
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal mineral absorption ( J:47419 )
• 2 hours after oral dosing with zinc, mice have about a 2-fold less zinc concentration in the blood than in control mice

homeostasis/metabolism
abnormal response to cardiac infarction ( J:85798 )
• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%
• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion
decreased myocardial infarct size ( J:85798 )
• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction
• area of tissue with infarctions visible is only about half that of non-transgenic controls

cardiovascular system
abnormal response to cardiac infarction ( J:85798 )
• the mean percentage of apoptotic cells present in the myocardium after ischemia/reperfusion is 14.4% compared to 26.3%
• myocardial oxidative damage is reduced by almost two-thirds as measured by levels of lipid peroxidation found in the heart after ischemia/reperfusion
decreased myocardial infarct size ( J:85798 )
• only small scattered infarct zones are present after ischemia/reperfusion-induced myocardial infarction
• area of tissue with infarctions visible is only about half that of non-transgenic controls




Genotype
MGI:4361627
tg3
Allelic
Composition		 Tg(Mt1)174Bri/0
Genetic
Background		 B6.Cg-Tg(Mt1)174Bri/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:120196 )
• treated-treated mice exhibit increased mean survival time compared with similarly treated wild-type mice

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:120196 )
• treated-treated mice exhibit increased mean survival time compared with similarly treated wild-type mice




Genotype
MGI:3798838
tg4
Allelic
Composition		 Tg(Mt1)174Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mt1)174Bri mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal mineral level ( J:29102 )
• mice have 50% more zinc in the liver and 3-fold more zinc in the pancreas than is found in non-transgenic littermate controls




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory