Phenotypes associated with this allele

• Allele Symbol: Foxo1^tm1Tf
• Allele Name: targeted mutation 1, Tatsuo Furuyama
• Allele ID: MGI:3052743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxo1^tm1Tf/Foxo1^tm1Tf	involves: C57BL/6J	MGI:3053394

Genotype
MGI:3053394

hm1

• Allelic Composition: Foxo1^tm1Tf/Foxo1^tm1Tf
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation, abnormal development of branchial arches and pericardial swelling in Foxo1^tm1Tf/Foxo1^tm1Tf mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92247 )

• homozygous embryos die around E11.5

cardiovascular system

abnormal dorsal aorta morphology ( J:92247 )

• at E9.5 the dorsal aorta is underdeveloped and abnormally formed

pharyngeal arch artery hypoplasia ( J:92247 )

• at E9.5 hypoplasia of the branchial arch arteries is seen with no arteries arising from the aortic sac

• however, formation of the 1st and 2nd arch arteries does occur

absent organized vascular network ( J:92247 )

• primary vascular plexi form in the head and yolk sac but are not remodeled into normal vasculature

pericardial effusion ( J:92247 )

• at E9.5 associated with the absence of the branchial arch arteries a large pericardial effusion is seen

embryo

pharyngeal arch artery hypoplasia ( J:92247 )

• at E9.5 hypoplasia of the branchial arch arteries is seen with no arteries arising from the aortic sac

• however, formation of the 1st and 2nd arch arteries does occur

small first pharyngeal arch ( J:92247 )

• at E9.5

absent second pharyngeal arch ( J:92247 )

• at E9.5

pharyngeal arch hypoplasia ( J:92247 )

• at E9.5 hypoplasia of the branchial arches is seen

embryonic growth retardation ( J:92247 )

• after E9.5 mutant embryos are growth retarded

abnormal visceral yolk sac morphology ( J:92247 )

• the visceral endoderm and mesoderm are only fused at discrete loci

abnormal vitelline vascular remodeling ( J:92247 )

• the vascular plexus forms but is not remodeled into a mature vascular network

growth/size/body

embryonic growth retardation ( J:92247 )

• after E9.5 mutant embryos are growth retarded

craniofacial

pharyngeal arch artery hypoplasia ( J:92247 )

• at E9.5 hypoplasia of the branchial arch arteries is seen with no arteries arising from the aortic sac

• however, formation of the 1st and 2nd arch arteries does occur

small first pharyngeal arch ( J:92247 )

• at E9.5

absent second pharyngeal arch ( J:92247 )

• at E9.5

pharyngeal arch hypoplasia ( J:92247 )

• at E9.5 hypoplasia of the branchial arches is seen

homeostasis/metabolism

pericardial effusion ( J:92247 )

• at E9.5 associated with the absence of the branchial arch arteries a large pericardial effusion is seen