About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chst2tm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:3052713
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chst2tm1Tmu/Chst2tm1Tmu involves: 129S2/SvPas * C57BL/6J MGI:3053811
cx2
 		Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr 		involves: 129S2/SvPas MGI:5543509
cx3
 		Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr 		involves: 129S2/SvPas * C57BL/6NTac MGI:5543506


Genotype
MGI:3053811
hm1
Allelic
Composition		 Chst2tm1Tmu/Chst2tm1Tmu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:92231 )
• decreased lymphocyte binding to peripheral lymph node high endothelial venules
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes

cellular
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes

hematopoietic system
abnormal leukocyte physiology ( J:92231 )
• decreased lymphocyte binding to peripheral lymph node high endothelial venules
abnormal leukocyte migration ( J:92231 )
• diminished lymphocyte homing in peyer's patches, peripheral and mesenteric lymph nodes




Genotype
MGI:5543509
cx2
Allelic
Composition		 Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (23 available)
Chst4tm1Sdr mutation (1 available); any Chst4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

hematopoietic system
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice

immune system
abnormal leukocyte migration ( J:204813 )
• mice exhibit reduced homing in the peripheral and mesenteric lymph nodes compared with control mice




Genotype
MGI:5543506
cx3
Allelic
Composition		 Chst1tm1(KOMP)Vlcg/Chst1tm1(KOMP)Vlcg
Chst2tm1Tmu/Chst2tm1Tmu
Chst4tm1Sdr/Chst4tm1Sdr
Genetic
Background		 involves: 129S2/SvPas * C57BL/6NTac
Cell Lines 10172A-D6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst1tm1(KOMP)Vlcg mutation (2 available); any Chst1 mutation (18 available)
Chst2tm1Tmu mutation (1 available); any Chst2 mutation (23 available)
Chst4tm1Sdr mutation (1 available); any Chst4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

cellular
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal

hematopoietic system
abnormal leukocyte migration ( J:204813 )
• mice exhibit increased L-selectin-dependent homing to the peripheral lymph nodes compared with control mice
• however, homing to mesenteric lymph nodes is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory