Phenotypes associated with this allele

• Allele Symbol: Gja8^dcm
• Allele Name: dense cataract and microphthalmia
• Allele ID: MGI:3052418
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja8^dcm/Gja8^dcm	BALB/c-Gja8^dcm	MGI:3052438

Genotype
MGI:3052438

hm1

• Allelic Composition: Gja8^dcm/Gja8^dcm
• Genetic Background: BALB/c-Gja8^dcm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:91434 )

• mean body weight is increased in mutants

vision/eye

abnormal iris morphology ( J:91434 )

• at E13 the iris is underdeveloped

• the normal iris pattern is missing at P14

abnormal pupil morphology ( J:91434 )

• the pupillary muscles are underdeveloped at P14

abnormal cornea morphology ( J:91434 )

• at E13 the cornea is underdeveloped

abnormal lens fiber morphology ( J:91434 )

• at E13 the longitudinal fibrillar structures are lost from the lens core

• from E14 on degeneration, vacuole formation, and swelling of lens fibers with lost longitudinal fibrillar structures are seen

• at P1 degenerative changes to the lens fibers continue leading to destruction of the nuclear area

cataract ( J:91434 )

• cataracts are first visible to the unaided eye at P14 and grow progressively more severe as the mice age

abnormal optic stalk morphology ( J:91434 )

• at E13 the optic stalk is underdeveloped

microphthalmia ( J:91434 )

abnormal retina morphology ( J:91434 )

• at E13 the retina is underdeveloped