Phenotypes associated with this allele

• Allele Symbol: Rph3al^tm1Sse
• Allele Name: targeted mutation 1, Susumu Seino
• Allele ID: MGI:3051976
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rph3al^tm1Sse/Rph3al^tm1Sse	B6.129-Rph3al^tm1Sse	MGI:3051996

Genotype
MGI:3051996

hm1

• Allelic Composition: Rph3al^tm1Sse/Rph3al^tm1Sse
• Genetic Background: B6.129-Rph3al^tm1Sse

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

pancreatic acinar cell zymogen granule accumulation ( J:90669 )

• accumulation of zymogen granules in acinar cells of exocrine pancreas

endocrine/exocrine glands

pancreatic acinar cell zymogen granule accumulation ( J:90669 )

• accumulation of zymogen granules in acinar cells of exocrine pancreas

decreased insulin secretion ( J:90669 )

• stress induced impaired Ca2+ triggered insulin secretion

homeostasis/metabolism

decreased insulin secretion ( J:90669 )

• stress induced impaired Ca2+ triggered insulin secretion

increased circulating glucose level ( J:90669 )

• stress induced a sustained rise in blood glucose levels

impaired glucose tolerance ( J:90669 )