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Allele Symbol Allele Name Allele ID |
Ptprn2tm1Aln targeted mutation 1, Abner Louis Notkins MGI:3051779 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• elevated glucose levels and decreased insulin release are seen in a glucose tolerance test however fasting and non-fasting blood glucose and insulin levels are within the normal range
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• on a mixed background including NOD cyclophosphamide induced diabetes occurs to the same extent in mutants as in wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:81889 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• double knockout male mice are fertile, unlike double mutant females; no alterations in testis histology or testis weight are observed at 12 weeks of age
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• lipid droplets are found in stromal cells at 7 weeks of age
• however, the number and appearance of oocytes and antral follicles is normal
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• corpora lutea are absent at 7 weeks and at 3 months of age
• however, large numbers of corpora lutea are formed within 96 h after PMSG + hCG treatment; hCG alone is not as effective as PMSG + hCG treatment
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• the typical LH surge required for ovulation is not observed at any of the times (i.e. daily) tested, unlike in wild-type controls
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• vaginal smears revealed total absence of a normal estrous cycle
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• double knockout females are essentially infertile, unlike single knockout females
• when mated with wild-type males, only 2 of 12 double knockout females produce offspring
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• when mated with wild-type males, only 2 of 12 double knockout females give birth and litter sizes are very small
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N |
• double knockout male mice show normal plasma LH and FSH levels at 4 months of age
• Western blot analysis revealed a non-significant (34%) reduction in the concentration of LH in pituitary lysates at 4 months of age
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• at 4 months of age, Western blot analysis revealed a 60% reduction in the concentration of FSH in pituitary lysates at proestrus
• however, basal FSH levels in the plasma are normal
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• at 4 months of age, Western blot analysis revealed a nearly 75% reduction in the concentration of LH in pituitary lysates at proestrus
• however, the concentration of LH is almost normal in pituitary lysates of pre-pubertal mice at 24 days of age
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• no typical LH surge is found in plasma during proestrus at 3-6 months of age, unlike in wild-type controls
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• lipid droplets are found in stromal cells at 7 weeks of age
• however, the number and appearance of oocytes and antral follicles is normal
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• corpora lutea are absent at 7 weeks and at 3 months of age
• however, large numbers of corpora lutea are formed within 96 h after PMSG + hCG treatment; hCG alone is not as effective as PMSG + hCG treatment
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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