Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b4tm1Ges mutation
(1 available);
any
Atp2b4 mutation
(54 available)
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Atp2b4tm1Ges/Atp2b4tm1Ges sperm tails exhibit an increase in the number of condensed mitochondria
reproductive system
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• hyperactivated sperm motility is severely impaired with most mutant sperm non-motile after 90 min in conditions that should result in hyperactivation
• in hyperactivating conditions mutant sperm have significantly more condensed mitochondria compared to wild-type sperm
• mutant sperm have normal motility in the epididymis
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• males but not females are infertile
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cellular
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• hyperactivated sperm motility is severely impaired with most mutant sperm non-motile after 90 min in conditions that should result in hyperactivation
• in hyperactivating conditions mutant sperm have significantly more condensed mitochondria compared to wild-type sperm
• mutant sperm have normal motility in the epididymis
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b4tm1Ges mutation
(1 available);
any
Atp2b4 mutation
(54 available)
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Atp2b4tm1Ges/Atp2b4tm1Ges portal vein smooth muscle shows an increase in apoptosis
behavior/neurological
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• excessive scratching is seen around the jaw and is correlated with an enlarged submandibular gland
• this phenotype is not seen on an inbred Black Swiss background
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immune system
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• the submandibular gland is enlarged
• this phenotype is not seen on an inbred Black Swiss background
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reproductive system
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• males but not females are infertile
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muscle
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• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
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cardiovascular system
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• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
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muscle
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• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background
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cardiovascular system
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• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background
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