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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr29Hxl3
hemimelic extra toes-like 3
MGI:3051414
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr29Hxl3/Rr29Hxl3 C57BL/6J-Rr29Hxl3 MGI:3051417
hm2
 		Rr29Hxl3/Rr29Hxl3 D2;B6-Rr29Hxl3/Rbrc MGI:3714747
ht3
 		Rr29Hxl3/Rr29+ C57BL/6J-Rr29Hxl3 MGI:3051418


Genotype
MGI:3051417
hm1
Allelic
Composition		 Rr29Hxl3/Rr29Hxl3
Genetic
Background		 C57BL/6J-Rr29Hxl3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hxl3 mutation (1 available); any Rr29 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:87798 )
• preaxial polydactyly
• supernumerary metacarpals, metatarsals, and digits
• hemimelia caused by shortening of the radius, tibia, and talus
• hindlimbs usually more affected than forelimbs




Genotype
MGI:3714747
hm2
Allelic
Composition		 Rr29Hxl3/Rr29Hxl3
Genetic
Background		 D2;B6-Rr29Hxl3/Rbrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hxl3 mutation (1 available); any Rr29 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
polydactyly ( J:121866 )
• more severe form of preaxial polydactyly than other Shh ENU mutants
• tripharangeal digit 1
abnormal tibia morphology ( J:121866 )
• tibia hemimelia

skeleton
abnormal tibia morphology ( J:121866 )
• tibia hemimelia




Genotype
MGI:3051418
ht3
Allelic
Composition		 Rr29Hxl3/Rr29+
Genetic
Background		 C57BL/6J-Rr29Hxl3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr29Hxl3 mutation (1 available); any Rr29 mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Skeletal phenotypes of Rr29Hx/Rr29Hx and Rr29Hxl3/Shh+ mice

limbs/digits/tail
polydactyly ( J:87798 )
• preaxial polydactyly
• supernumerary metacarpals, metatarsals, and digits
• hemimelia caused by shortening of the radius, tibia, and talus
• hindlimbs usually more affected than forelimbs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory