All Phenotypes Tg(MMTV-Erbb2)NF1Mul MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MMTV-Erbb2)NF1Mul/0	FVB/N-Tg(MMTV-Erbb2)NF1Mul	MGI:3785834
tg2	Tg(MMTV-Erbb2)NF1Mul/0	involves: CD-1 * FVB/N	MGI:3785827
tg3	Tg(MMTV-Erbb2)NF1Mul/0	involves: FVB/N	MGI:3785826

Allelic Composition	Tg(MMTV-Erbb2)NF1Mul/0
Genetic Background	FVB/N-Tg(MMTV-Erbb2)NF1Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

Allelic Composition	Tg(MMTV-Erbb2)NF1Mul/0
Genetic Background	involves: CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal epididymis epithelium morphology ( J:48632 )

• male mice exhibit bilateral papillary hyperplasia that protrudes into the lumen of the epididymis

reduced male fertility ( J:48632 )

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

abnormal parotid gland morphology ( J:48632 )

• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium

increased parotid gland size ( J:48632 )

• the parotid gland of male mice weighs five times more than in wild-type mice

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

behavior/neurological

abnormal nursing ( J:48632 )

• females fail to nurse

digestive/alimentary system

abnormal parotid gland morphology ( J:48632 )

• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium

increased parotid gland size ( J:48632 )

• the parotid gland of male mice weighs five times more than in wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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