Analysis Tools
endocrine/exocrine glands
small testis
(
J:91483
)
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• a 10-15% size reduction in about 10% of males
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reproductive system
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• spermatozoa are less motile
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• only about 35% as much sperm in epididymis as found in wild-type mice
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• mutant epididymal sperm exhibit many structural abnormalities
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• in some cases, the bend in the tail is adjacent to the nucleus
• 80% of mutant epididymal sperm have tails with hairpin loops, exhibiting a 180 bend in the principal piece, as opposed to 15% in wild-type
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• ~50% of male homozygotes exhibit an exceptionally high number of spermatozoa with abnormally shaped heads
• the back of the sperm head is frequently malformed and more angular in shape
• some mutant heads also display a very short apex
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• acrosomal malformations with elongated projections are observed
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• many sperm cells exhibit a detached acrosome
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• aberrantly shaped sperm heads display defects in the compaction of nuclear chromatin
• nuclear vacuoles and severe nuclear malformations are observed
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small testis
(
J:91483
)
|
|
• a 10-15% size reduction in about 10% of males
|
|
|
• cauda epididymis is always smaller and more transparent than wild-type
|
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• male fertility is apparently delayed about 1 month but otherwise normal
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cellular
|
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• only about 35% as much sperm in epididymis as found in wild-type mice
|
|
|
• mutant epididymal sperm exhibit many structural abnormalities
|
|
|
• 80% of mutant epididymal sperm have tails with hairpin loops, exhibiting a 180 bend in the principal piece, as opposed to 15% in wild-type
• in some cases, the bend in the tail is adjacent to the nucleus
|
|
|
• ~50% of male homozygotes exhibit an exceptionally high number of spermatozoa with abnormally shaped heads
• the back of the sperm head is frequently malformed and more angular in shape
• some mutant heads also display a very short apex
|
|
|
• acrosomal malformations with elongated projections are observed
|
|
|
• many sperm cells exhibit a detached acrosome
|
|
|
• aberrantly shaped sperm heads display defects in the compaction of nuclear chromatin
• nuclear vacuoles and severe nuclear malformations are observed
|
|
|
• spermatozoa are less motile
|
