Phenotypes associated with this allele

• Allele Symbol: Gnas^tm1Jop
• Allele Name: targeted mutation 1, Jo Peters
• Allele ID: MGI:3050794
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gnas^tm1Jop/Gnas^+	involves: 129S/SvEv * C57BL/6	MGI:3051502
ht2	Gnas^Oedsml/Gnas^tm1Jop	involves: 129S/SvEv * C57BL/6	MGI:3051503

Genotype
MGI:3051502

ht1

• Allelic Composition: Gnas^tm1Jop/Gnas⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:91717 )

• mice carrying the allele, regardless if its inherited maternally or paternally, are viable, healthy, and fertile

Genotype
MGI:3051503

ht2

• Allelic Composition: Gnas^Oedsml/Gnas^tm1Jop
• Genetic Background: involves: 129S/SvEv * C57BL/6

cardiovascular system

abnormal heart size ( J:91717 )

• the heart weight to body length ratio is significantly reduced compared to wild-type littermates, however neither heart weight nor body length alone are significantly reduced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:91717 )

N • unlike Gnas^Oedsml-mat heterozygotes, compound heterozygotes are viable and do not display hypocalcemia, hyperphosphatemia, elevated circulating parathyroid hormone levels, gross edema, or brown fat abnormalities