Phenotypes associated with this allele

• Allele Symbol: Kcnk2^tm1Lzd
• Allele Name: targeted mutation 1, Michel Lazdunski
• Allele ID: MGI:3050220
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk2^tm1Lzd/Kcnk2^tm1Lzd	involves: 129 * C57BL/6J	MGI:3050295
cx2	Kcnk10^tm1Fles/Kcnk10^tm1Fles Kcnk2^tm1Lzd/Kcnk2^tm1Lzd Kcnk4^tm1Lzd/Kcnk4^tm1Lzd	B6.Cg-Kcnk2^tm1Lzd Kcnk10^tm1Fles Kcnk4^tm1Lzd	MGI:3836808

Genotype
MGI:3050295

hm1

• Allelic Composition: Kcnk2^tm1Lzd/Kcnk2^tm1Lzd
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:91531 )

• increased mortality following transient ischemia is seen

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91531 )

• increased mortality from kainic acid or pentylenetetrazol exposures is seen

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:91531 )

• increased sensitivity to kainic acid- and pentylenetetrazol-induced seizures

• linolenic acid and lysophosphatidylcholine do not protect against kainic acid-induced seizures unlike in wild-type mice

impaired behavioral response to xenobiotic ( J:91531 )

• decreased sensitivity to volatile anesthetics including; chloroform, halothane, sevoflurane, desflurane, and isoflurane, is seen

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91531 )

• increased mortality from kainic acid or pentylenetetrazol exposures is seen

decreased physiological sensitivity to xenobiotic ( J:91531 )

• the minimum alveolar anesthetic concentrations for volatile anesthetics are increased

abnormal response to CNS ischemic injury ( J:91531 )

• increased mortality and paralysis are seen following combined occlusion of the aortic arch and left subclavian artery to induce spinal cord ischemia

increased susceptibility to ischemic brain injury ( J:91531 )

• increased mortality and seizure incidence are seen following transient bilateral occlusion of the common carotid arteries during systemic hypotension

nervous system

increased susceptibility to pharmacologically induced seizures ( J:91531 )

• increased sensitivity to kainic acid- and pentylenetetrazol-induced seizures

• linolenic acid and lysophosphatidylcholine do not protect against kainic acid-induced seizures unlike in wild-type mice

abnormal response to CNS ischemic injury ( J:91531 )

• increased mortality and paralysis are seen following combined occlusion of the aortic arch and left subclavian artery to induce spinal cord ischemia

increased susceptibility to ischemic brain injury ( J:91531 )

• increased mortality and seizure incidence are seen following transient bilateral occlusion of the common carotid arteries during systemic hypotension

Genotype
MGI:3836808

cx2

• Allelic Composition: Kcnk10^tm1Fles/Kcnk10^tm1Fles; Kcnk2^tm1Lzd/Kcnk2^tm1Lzd; Kcnk4^tm1Lzd/Kcnk4^tm1Lzd
• Genetic Background: B6.Cg-Kcnk2^tm1Lzd Kcnk10^tm1Fles Kcnk4^tm1Lzd

nervous system

nervous system phenotype ( J:145944 )

N • mice exhibit normal hyperpolarization of hypothalamic neurons in response to glucose