Analysis Tools|
Allele Symbol Allele Name Allele ID |
Smurf2+ wild type MGI:3050217 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop tumors within 20 months
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• in some mice
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• in mouse embryonic fibroblasts under a 3T9 protocol
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present 24 hours after birth (10% compared to the expected 25%)
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• occasionally looped
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• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/28/2026 MGI 6.24 |
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