Phenotypes associated with this allele

• Allele Symbol: Mus81^tm1Raz
• Allele Name: targeted mutation 1, Razqallah Hakem
• Allele ID: MGI:3050210
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mus81^tm1Raz/Mus81^tm1Raz	involves: 129P2/OlaHsd	MGI:3050290
ht2	Mus81^tm1Raz/Mus81^+	involves: 129P2/OlaHsd	MGI:3050292

Genotype
MGI:3050290

hm1

• Allelic Composition: Mus81^tm1Raz/Mus81^tm1Raz
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:91570 )

• mutants are slightly more sensitve to 9 Gy gamma irradiation but not to 7 Gy gamma irradiation

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91570 )

• mutants display increased sensitivity to mitomycin c induced lethality

premature death ( J:91570 )

• only 27% of homozygotes survive to 1 year compared to 95% of wild-type littermates

neoplasm

increased lymphoma incidence ( J:91570 )

• mutants have a non-Hodgkin's lymphoma incidence of 1.00

• 2 out of 12 lymphomas showed metastatic potential

increased B cell derived lymphoma incidence ( J:91570 )

• 3 out of 3 lymphomas examined were classified as B cell derived

increased carcinoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and either comedocarcinoma of the neck or ovarian carcinoma

cellular

chromosome breakage ( J:91570 )

• T cell metaphase spreads show increased chromosomal abnormalities

• mutants display increased sensitivity to mitomycin c induced sister chromatid exchange

immune system

immune system phenotype ( J:91570 )

N • mutants display normal lymphocyte development and activation induced proliferation

reproductive system

reproductive system phenotype ( J:91570 )

N • mutants are fertile with no apparent defect in gametogenesis

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:91570 )

• mutants are slightly more sensitve to 9 Gy gamma irradiation but not to 7 Gy gamma irradiation

increased susceptibility to xenobiotic induced morbidity/mortality ( J:91570 )

• mutants display increased sensitivity to mitomycin c induced lethality

Genotype
MGI:3050292

ht2

• Allelic Composition: Mus81^tm1Raz/Mus81⁺
• Genetic Background: involves: 129P2/OlaHsd

mortality/aging

premature death ( J:91570 )

• only 50% of heterozygotes survive to 1 year compared to 95% of wild-type littermates

neoplasm

increased adenoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and adenoma of the prostate, bladder, or colon

increased lymphoma incidence ( J:91570 )

• mutants have a non-Hodgkin's lymphoma incidence of 0.97

• 7 out of 33 lymphomas showed metastatic potential

• heterozygous mutants had either B cell (5/12) or T cell (7/12) derived lymphomas

increased carcinoma incidence ( J:91570 )

• several mutants displayed multiple cancers including lymphoma and ductal carcinoma

cellular

chromosome breakage ( J:91570 )

• T cell metaphase spreads show increased chromosomal abnormalities including a mild propensity for aneuploidy

• mutants display increased sensitivity to mitomycin c induced sister chromatid exchange