Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd6tm1Nat mutation
(1 available);
any
Fzd6 mutation
(42 available)
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integument
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• abnormal hair patterns are seen on the dorsal surface of the head, the hind feet, the back, and chest
• in the regions with abnormal hair patterns hair follicles do not conform to the parallel arrangement seen elsewhere
• penetrance is higher on a pure 129 background than on a mixed 129 - C57BL/6 background
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd6tm1Nat mutation
(1 available);
any
Fzd6 mutation
(42 available)
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integument
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• abnormal hair patterns are seen on the dorsal surface of the head, the hind feet, the back, and chest
• in the regions with abnormal hair patterns hair follicles do not conform to the parallel arrangement seen elsewhere
• penetrance is higher on a pure 129 background than on a mixed 129 - C57BL/6 background
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Astn2tm1.2Nat mutation
(0 available);
any
Astn2 mutation
(60 available)
Fzd6tm1Nat mutation
(1 available);
any
Fzd6 mutation
(42 available)
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integument
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• hair ridge on back coat between upper and lower back
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• posterior-to-anterior and weaker lateral directional bias on lower back
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integument
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• hair ridge on back coat between upper and lower back
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• posterior-to-anterior and weaker lateral directional bias on lower back
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mortality/aging
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• all die within minutes of birth
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nervous system
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• most severe hair bundle orientation defects in the inner hair cells
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• less abnormality in the outer row of outer hair cells
• minimal abnormality in the inner two rows of outer hair cells
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hearing/vestibular/ear
N |
• utricle and saccule hair cells of the vestibule are more or less normal
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• most severe hair bundle orientation defects in the inner hair cells
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• less abnormality in the outer row of outer hair cells
• minimal abnormality in the inner two rows of outer hair cells
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• hair bundle orientation defects in the cristae
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limbs/digits/tail
vision/eye
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• in about 10% of mice, eyelids fail to fuse
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embryo
reproductive system
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• 10 fold reduction in sperm count
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cellular
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• 10 fold reduction in sperm count
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