Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tsga10+ wild type MGI:3049979 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by inspection of transmission electron micrographs, the arrangement of mitochondria in the midpiece of spermatozoa was disturbed
• Morphological and histological examination of the testes of WT and heterozygous mice showed no gross differences.
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• Sperm motility (A + B) was significantly lower.
• The serum FSH and LH levels of Tsga10+/ male mice were similar.
• The acrosome reaction occurred normally in the heterozygous.
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• by inspection of transmission electron micrographs, the arrangement of mitochondria in the midpiece of spermatozoa was disturbed
• Morphological and histological examination of the testes of WT and heterozygous mice showed no gross differences.
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• Sperm motility (A + B) was significantly lower.
• The serum FSH and LH levels of Tsga10+/ male mice were similar.
• The acrosome reaction occurred normally in the heterozygous.
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• the number of spermatozoa obtained from the Tsga10+/ mice was substantially lower than that obtained from the wild types
• There was no significant difference between Tsga10+/+ and Tsga10+/ mice in the sperm number from cauda epididymides
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• The heterozygous males, when mated with WT or Tsga10+/ females, never produced any pups within the observation period (2-6 months of cohabitation).
• Tsga10+/ female mice produced offspring at a similar rate to that of WT female mice when mated with WT males.
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• The spermatozoa from the heterozyogous male also appeared to have a reduced capacity to fertilize wild-type oocytes in vitro
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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