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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thap11+
wild type
MGI:3049881
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hcfc1em1Poche/Hcfc1+
Thap11em1Poche/Thap11+ 		C57BL/6J-Thap11em1Poche Hcfc1em1Poche MGI:6861794
cx2
 		Hcfc1em1Poche/Y
Thap11em1Poche/Thap11+ 		C57BL/6J-Thap11em1Poche Hcfc1em1Poche MGI:6861799


Genotype
MGI:6861794
cx1
Allelic
Composition		 Hcfc1em1Poche/Hcfc1+
Thap11em1Poche/Thap11+
Genetic
Background		 C57BL/6J-Thap11em1Poche Hcfc1em1Poche
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc1em1Poche mutation (0 available); any Hcfc1 mutation (7 available)
Thap11em1Poche mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal craniofacial morphology ( J:317822 )
• 2 of 3 adult mice exhibit craniofacial dysmorphia
abnormal nasal bone morphology ( J:317822 )
• mice exhibit a tilted nasal angle

limbs/digits/tail

integument
belly spot ( J:317822 )
• 1 of 11 adults shows a white belly spot

pigmentation
belly spot ( J:317822 )
• 1 of 11 adults shows a white belly spot

skeleton
abnormal nasal bone morphology ( J:317822 )
• mice exhibit a tilted nasal angle
vertebral transformation ( J:317822 )
• homeotic transformation is seen in 1 of 6 mutants at E16.5

respiratory system
abnormal nasal bone morphology ( J:317822 )
• mice exhibit a tilted nasal angle

growth/size/body
abnormal nasal bone morphology ( J:317822 )
• mice exhibit a tilted nasal angle




Genotype
MGI:6861799
cx2
Allelic
Composition		 Hcfc1em1Poche/Y
Thap11em1Poche/Thap11+
Genetic
Background		 C57BL/6J-Thap11em1Poche Hcfc1em1Poche
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc1em1Poche mutation (0 available); any Hcfc1 mutation (7 available)
Thap11em1Poche mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
vertebral transformation ( J:317822 )
• homeotic transformation is seen in 1 of 6 mutants at E16.5

mortality/aging

limbs/digits/tail
kinked tail ( J:317822 )
• a kinked tail is seen in 2 of 6 mutants at E16.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory